Repositioning Candidate Details
| Candidate ID: | R1356 |
| Source ID: | DB11242 |
| Source Type: | approved; vet_approved |
| Compound Type: | small molecule |
| Compound Name: | Gelatin |
| Synonyms: | Gelatin, unspecified; Gelatine |
| Molecular Formula: | -- |
| SMILES: | -- |
| DrugBank Description: | Gelatin is a multifunctional ingredient that is used in foods, pharmaceuticals, cosmetics, and photographic films as a gelling agent, stabilizer, thickener, emulsifier, as well as film former . As a thermoreversible hydrocolloid with a small gap between its melting and gelling temperatures, gelatin provides unique advantages over carbohydrate-based gelling agents. Gelatin is mainly produced from porcine skin, and cattle hides and bones . Some alternative raw substances have recently garnered attention from both researchers and the industry not only because they overcome religious concerns shared by both Jews and Muslims but also because they may provide scientific advantages over gelatins from mammal origins . Fish skins from a number of fish species a type of substance that has been comprehensively studied as a source for gelatin production. Fish skins have a significant potential for the production of high-quality gelatin with different melting and gelling temperatures over a much larger range than mammalian gelatins but have a sufficiently high level of gel strength and viscosity . Gelatin is generally recognized as safe (GRAS) by the FDA to be a non-hazardous food or food ingredient . Interestingly, horse gelatin has been studied and it was found that in the horse, gelatin influences the homeostasis of the amino acids required for cartilage synthesis . An increasing number of novel applications have been found for collagen and gelatin . |
| CAS Number: | 9000-70-8 |
| Molecular Weight: | |
| DrugBank Indication: | Gelatin is used for weight loss and for treating osteoarthritis, rheumatoid arthritis, and brittle bones (osteoporosis). Some people also use it for strengthening bones, joints, and fingernails. Gelatin is also used for improving hair condition and to shorten the recovery after exercise and sports-related injury . Gelatin is used in preparations of foods, cosmetics, and medicine . Plasma volume expander in hypovolaemic shock . Haemostatic . Gelatin-based hydrogels are being used in drug delivery and tissue engineering because they are able to promote cell adhesion and proliferation. In addition, these hydrogels can be used as wound dressings because of their attractive fluid absorbance properties. Manufacturing technologies such as ultraviolet stereolithography and two-photon polymerization can be used to prepare structures containing photosensitive gelatin-based hydrogels . |
| DrugBank Pharmacology: | Gelatin contains collagen, which is one of the materials that make up cartilage and bone . In addition to their well-established value as a nutritional protein source, collagen and collagen-derived products may exhibit various potential biological activities on cells and the extracellular matrix through the corresponding food-derived peptides post-ingestion. This could justify their applications in dietary supplements and pharmaceutical agents . Gelatin is a protein that is used as a hemostatic in surgical procedures. It is also used as a plasma volume expander in hypovolemic shock. Gelatin rods structures may also be used to temporarily block tear outflow in cases of dry eye . |
| DrugBank MoA: | It works as a hemostatic by providing a physical framework within which clotting may occur . As a volume expander, gelatin remains in the vascular space. When used in the treatment of hypovolaemia gelatin can produce a significant increase in blood volume, cardiac output, stroke volume, blood pressure, urinary output and oxygen delivery, increasing volume and pressure . For intravascular volume expansion, the majority or gelatins produce an effect which is almost equivalent to of which are mild, although severe reactions albumin, with a duration of action of 3 to 4 hours to have been reported . Gelatin or collagen chains suspended in solution can be covalently cross-linked to form matrices that are able to swell in the presence of aqueous solutions, forming what are called _gelatin hydrogels_. Hydrogels, characterized by their hydrophilicity and insolubility in water, have the capability of swelling into an equilibrium volume while maintaining their shape. The chemical cross-linkers used may be either small bifunctional molecules or polyfunctional macromolecules, for example, glutaraldehyde . |
| Targets: | -- |
| Inclusion Criteria: | Indication associated |
| Diseases ID | DO ID | Disease Name | Definition | Class | |
|---|---|---|---|---|---|
| I16 | 6713 | Cerebrovascular disease | An vascular disease that is characterized by dysfunction of the blood vessels supplying the brain. http://en.wikipedia.org/wiki/Cerebrovascular_disease, http://www.ncbi.nlm.nih.gov/books/NBK378/ | disease of anatomical entity/ cardiovascular system disease/ vascular disease/cerebrovascular disease | Details |
| I15 | 1290 | Bone disease | A connective tissue disease that affects the structure or development of bone or causes an impairment of normal bone function. http://en.wikipedia.org/wiki/Bone_disease | disease of anatomical entity/ musculoskeletal system disease/connective tissue disease | Details |