Repositioning Candidate Details
| Candidate ID: | R1482 |
| Source ID: | DB13167 |
| Source Type: | approved; withdrawn |
| Compound Type: | small molecule |
| Compound Name: | Alclofenac |
| Synonyms: | [4-(allyloxy)-3-chlorophenyl]acetic acid; 3-Chloro-4-(2-propenyloxy)benzeneacetic acid; Alclofenac; Alclophenac |
| Molecular Formula: | C11H11ClO3 |
| SMILES: | OC(=O)CC1=CC(Cl)=C(OCC=C)C=C1 |
| Structure: |
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| DrugBank Description: | Alclofenac is a non-steroidal anti-inflammatory drug. It was withdrawn from the market in the United Kingdom in 1979. |
| CAS Number: | 22131-79-9 |
| Molecular Weight: | 226.66 |
| DrugBank Indication: | Alclofenac is indicated in rheumatology, in particular for the treatment of rheumatoid arthritis, ankylosing spondylitis and, as an analgesic, in painful arthritic pathologies. |
| DrugBank Pharmacology: | -- |
| DrugBank MoA: | Alclofenac is an inhibitor of prostaglandin H2 synthase. The inhibition of the enzyme occurs through the reversible block of cyclooxygenase enzyme. Therefore, it prevents the production of inflammatory mediators (and pain) as prostacyclins and prostaglandins. Aclofenac has the ability to inhibit the biosynthesis of prostaglandins which may be an important factor in the action of these drugs, but in addition, the effect of these agents in displacing endogenous anti-inflammatory substances from plasma protein binding sites is thought to be an equally important effect in their mechanism of action |
| Targets: | Prostaglandin G/H synthase 2 antagonist |
| Inclusion Criteria: | Therapeutic strategy associated |
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs | |
|---|---|---|---|---|---|
| S05 | Anti-inflammatory | inflammatory | Bile acid; TNF-a inhibitor; Dual PPAR-α and -δ agonists; Toll-Like Receptor; (TLR)-4 antagonist; Caspase inhibitor; ASK-1 inhibitor | Ursodeoxycholic Acid; Pentoxifylline; Elafibranor; JKB-121; Emricasan; Selonsertib; | Details |
| Diseases ID | DO ID | Disease Name | Definition | Class | |
|---|---|---|---|---|---|
| I15 | 1290 | Bone disease | A connective tissue disease that affects the structure or development of bone or causes an impairment of normal bone function. http://en.wikipedia.org/wiki/Bone_disease | disease of anatomical entity/ musculoskeletal system disease/connective tissue disease | Details |