Repositioning Candidate Details
| Candidate ID: | R0176 |
| Source ID: | DB00521 |
| Source Type: | approved |
| Compound Type: | small molecule |
| Compound Name: | Carteolol |
| Synonyms: | -- |
| Molecular Formula: | C16H24N2O3 |
| SMILES: | CC(C)(C)NCC(O)COC1=CC=CC2=C1CCC(=O)N2 |
| Structure: |
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| DrugBank Description: | A beta-adrenergic antagonist used as an anti-arrhythmia agent, an anti-angina agent, an antihypertensive agent, and an antiglaucoma agent. |
| CAS Number: | 51781-06-7 |
| Molecular Weight: | 292.3734 |
| DrugBank Indication: | For the treatment of intraocular hypertension and chronic open-angle glaucoma |
| DrugBank Pharmacology: | Carteolol is a beta1 and beta2 (non-selective) adrenergic receptor-blocking agent that does not have significant intrinsic sympathomimetic, direct myocardial depressant, or local anesthetic (membrane-stabilizing) activity. Carteolol, when applied topically to the eye, has the action of reducing elevated, as well as normal, intraocular pressure, whether or not accompanied by glaucoma. Elevated intraocular pressure is a major risk factor in the pathogenesis of glaucomatous visual field loss and optic nerve damage. Carteolol reduces intraocular pressure with little or no effect on pupil size or accommodation in contrast to the miosis which cholinergic agents are known to produce. |
| DrugBank MoA: | The primary mechanism of the ocular hypotensive action of carteolol in reducing intraocular pressure is most likely a decrease in aqueous humor production. This process is initiated by the non-selective beta1 and beta2 adrenergic receptor blockade. |
| Targets: | Beta-2 adrenergic receptor antagonist; Beta-1 adrenergic receptor partial agonist |
| Inclusion Criteria: | Indication associated |
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
|---|
| Diseases ID | DO ID | Disease Name | Definition | Class | |
|---|---|---|---|---|---|
| I12 | 10763 | Hypertension | An artery disease characterized by chronic elevated blood pressure in the arteries. https://en.wikipedia.org/wiki/Hypertension, https://www.ncbi.nlm.nih.gov/pubmed/24352797 | disease of anatomical entity/ cardiovascular system disease/vascular disease/ artery disease | Details |