Repositioning Candidate Details
| Candidate ID: | R0033 |
| Source ID: | DB00116 |
| Source Type: | nutraceutical |
| Compound Type: | small molecule |
| Compound Name: | Tetrahydrofolic acid |
| Synonyms: | 5,6,7,8-tetrahydrofolate; 5,6,7,8-tetrahydrofolic acid; Tetrahydrofolate |
| Molecular Formula: | C19H23N7O6 |
| SMILES: | NC1=NC(=O)C2=C(NCC(CNC3=CC=C(C=C3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)N2)N1 |
| Structure: |
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| DrugBank Description: | Tetrahydrofolic acid is a folic acid derivative that is produced from dihydrofolic acid after conversion by dihydrofolate reductase. It is converted into 5,10-methylenetetrahydrofolate by serine hydroxymethyltransferase. It is a soluble coenzyme in many reactions, especially in the metabolism of amino acids and nucleic acids. |
| CAS Number: | 135-16-0 |
| Molecular Weight: | 445.4292 |
| DrugBank Indication: | For nutritional supplementation, also for treating dietary shortage or imbalance. |
| DrugBank Pharmacology: | Tetrahydrofolate is the main active metabolite of dietary folate. It is vital as a coenzyme in reactions involving transfers of single carbon groups. Tetrahydrofolate has a role in nucleic and amino acid synthesis. As nucleic and amino acid synthesis is affected by a deficiency of tetrahydrofolate, actively dividing and growing cells tend to be the first affected. Tetrahydrofolate is used to treat topical sprue and megaloblastic and macrocytic anemias, hematologic complications resulting from a deficiency in folic acid. |
| DrugBank MoA: | Tetrahydrofolate is transported across cells by receptor-mediated endocytosis where it is needed to maintain normal erythropoiesis, synthesize purine and thymidylate nucleic acids, interconvert amino acids, methylate tRNA, and generate and use formate. |
| Targets: | C-1-tetrahydrofolate synthase, cytoplasmic cofactor; Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial cofactor; Aminomethyltransferase, mitochondrial cofactor; Cytosolic 10-formyltetrahydrofolate dehydrogenase cofactor; Methionine synthase cofactor; Formimidoyltransferase-cyclodeaminase cofactor; Bifunctional purine biosynthesis protein PURH cofactor; Serine hydroxymethyltransferase, cytosolic cofactor; Serine hydroxymethyltransferase, mitochondrial cofactor; Methylenetetrahydrofolate reductase cofactor; Serine hydroxymethyltransferase cofactor; Methionyl-tRNA formyltransferase, mitochondrial cofactor |
| Inclusion Criteria: | Indication associated |
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
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| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
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| Diseases ID | DO ID | Disease Name | Definition | Class | |
|---|---|---|---|---|---|
| I02 | 5113 | Nutritional deficiency disease | A nutrition disease that is characterized by deficiency of a nutritional element, such as a vitamin, mineral, carbohydrate, protein, fat, or general energy content. https://medlineplus.gov/malnutrition.html | disease of metabolism/acquired metabolic disease/nutrition disease | Details |