Associated Disease Details

Disease ID: I02
DO ID: 5113
Disease Name: Nutritional deficiency disease
Definition: A nutrition disease that is characterized by deficiency of a nutritional element, such as a vitamin, mineral, carbohydrate, protein, fat, or general energy content. https://medlineplus.gov/malnutrition.html
Synonyms: Carnitine deficiency; Folic Acid Deficiency; Mineral deficiency; Vitamin B 12 Deficiency; Vitamin B 6 Deficiency; Vitamin D Deficiency; Vitamin Deficiency; Vitamin E Deficiency; Vitamin D-dependent rickets; Vitamin D-Resistant Rickets, X-Linked; dietary shortage or imbalance; Nutritional deficiency
Class: disease of metabolism/acquired metabolic disease/nutrition disease
Related Drugs: Alpha-tocopherol; Carnitine complex; Citrulline; DHA; Ergocalciferol; Folic acid; Glutathione; L-alanine; L-Carnitine; Niacin; Olive oil; S-adenosyl-L-methionine; Testosterone Undecanoate; Vitamin B12; Vitamin B6; Vitamin C; Vitamin E;
Mechanism: A series of studies revealed the pivotal role of gut microbiota (GM) dysbiosis in NAFLD's pathogenesis. The GM plays an essential role in different metabolic pathways, including the fermentation of diet polysaccharides, energy harvest, choline regulation, and bile acid metabolism. One of the most critical factors in GM stabilization is the diet; therefore, nutritional therapyappearsto be a promising tool in NAFLD therapy.
Reference (PMIDs): 33567710

Drug ID Drug Name Type DrugBank ID Targets Category Latest Progress
D240 Nicotinamide Chemical drug DB02701 PARP inhibitor Metabolic disorder drug Under clinical trials Details

Candidate ID Source ID Source Type Compound Type Candidate Name Inclusion Criteria
R1363 DB11321 nutraceutical; vet_approved small molecule Cod liver oil Indication associated Details
R1505 DB13949 approved small molecule Ferric cation Therapeutic strategy associated Details

Article ID PMID Source Title
A06385 32900869 mSystems Dietary Intervention Reverses Fatty Liver and Altered Gut Microbiota during Early-Life Undernutrition. Details
A13128 30127297 Nutrients Evaluation of a High Concentrate Omega-3 for Correcting the Omega-3 Fatty Acid Nutritional Deficiency in Non-Alcoholic Fatty Liver Disease (CONDIN). Details
A49810 35630058 Medicina (Kaunas) Chronic Inflammation-A Link between Nonalcoholic Fatty Liver Disease (NAFLD) and Dysfunctional Adipose Tissue. Details
A53080 15520626 MedGenMed Etiology and pathogenesis of necrolytic migratory erythema: review of the literature. Details