Repositioning Candidate Details
| Candidate ID: | R0039 |
| Source ID: | DB00127 |
| Source Type: | experimental; nutraceutical |
| Compound Type: | small molecule |
| Compound Name: | Spermine |
| Synonyms: | 4,9-diaza-1,12-dodecanediamine; 4,9-diazadodecane-1,12-diamine; Musculamine; N,N'-Bis(3-aminopropyl)-1,4-butanediamine; Spermine |
| Molecular Formula: | C10H26N4 |
| SMILES: | NCCCNCCCCNCCCN |
| Structure: |
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| DrugBank Description: | Spermine is a spermidine-derived biogenic polyamine found as a polycation at all pH values. Found in various tissues and organisms, it often acts as an essential growth factor in some bacterial species. Spermine is associated with nucleic acids, particularly in viruses, and is thought to stabilize the helical structure. |
| CAS Number: | 71-44-3 |
| Molecular Weight: | 202.3402 |
| DrugBank Indication: | For nutritional supplementation, also for treating dietary shortage or imbalance |
| DrugBank Pharmacology: | Spermine is a polyamine. It is an organic molecule that is involved in cellular metabolism. |
| DrugBank MoA: | Spermine is derived from spermidine by spermine synthase. Spermine is a polyamine, a small organic cations that is absolutely required for eukaryotic cell growth. Spermine, is normally found in millimolar concentrations in the nucleus. Spermine functions directly as a free radical scavenger, and forms a variety of adducts that prevent oxidative damage to DNA. Oxidative damage to DNA by reactive oxygen species is a continual problem that cells must guard against to survive. Hence, spermine is a major natural intracellular compound capable of protecting DNA from free radical attack. Spermine is also implicated in the regulation of gene expression, the stabilization of chromatin, and the prevention of endonuclease-mediated DNA fragmentation. |
| Targets: | Spermine synthase ligand; Spermine oxidase ligand; DNA binder; Ornithine decarboxylase product of; Extracellular calcium-sensing receptor; Beta-1 adrenergic receptor; Beta-2 adrenergic receptor |
| Inclusion Criteria: | Indication associated |
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
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| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
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| Diseases ID | DO ID | Disease Name | Definition | Class | |
|---|---|---|---|---|---|
| I02 | 5113 | Nutritional deficiency disease | A nutrition disease that is characterized by deficiency of a nutritional element, such as a vitamin, mineral, carbohydrate, protein, fat, or general energy content. https://medlineplus.gov/malnutrition.html | disease of metabolism/acquired metabolic disease/nutrition disease | Details |