Repositioning Candidate Details
| Candidate ID: | R0042 |
| Source ID: | DB00131 |
| Source Type: | approved; investigational; nutraceutical |
| Compound Type: | small molecule |
| Compound Name: | Adenosine phosphate |
| Synonyms: | 5'-Adenosine monophosphate; 5'-Adenylic acid; 5'-AMP; 5'-O-Phosphonoadenosine; Adenosine 5'-(dihydrogen phosphate); Adenosine 5'-monophosphate; Adenosine 5'-phosphate; Adenosine monophosphate; Adenosine phosphate; Adenosine-5'-Monophosphate; Adenosine-5'-monophosphoric acid; Adenosine-5'P; Adenylate; Adenylic acid; Ado5'P; AMP; PAdo |
| Molecular Formula: | C10H14N5O7P |
| SMILES: | NC1=C2N=CN([C@@H]3O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]3O)C2=NC=N1 |
| Structure: |
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| DrugBank Description: | Adenylic acid. Adenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position. |
| CAS Number: | 61-19-8 |
| Molecular Weight: | 347.2212 |
| DrugBank Indication: | For nutritional supplementation, also for treating dietary shortage or imbalance |
| DrugBank Pharmacology: | Adenosine monophosphate, also known as 5'-adenylic acid and abbreviated AMP, is a nucleotide that is found in RNA. It is an ester of phosphoric acid with the nucleoside adenosine. AMP consists of the phosphate group, the pentose sugar ribose, and the nucleobase adenine. AMP is used as a dietary supplement to boost immune activity, and is also used as a substitute sweetener to aid in the maintenance of a low-calorie diet. |
| DrugBank MoA: | Nucleotides such as Adenosine-5'-Monophosphate affect a number of immune functions, including the reversal of malnutrition and starvation-induced immunosuppression, the enhancement of T-cell maturation and function, the enhancement of natural killer cell activity, the improvement of delayed cutaneous hypersensitivity, helping resistance to such infectious agents as Staphylococcus aureus and Candida albicans, and finally the modulation of T-cell responses toward type 1 CD4 helper lymphocytes or Th1 cells. Studies have shown that mice fed a nucleotide-free diet have both impaired humoral and cellular immune responses. The addition of dietary nucleotides normalizes both types of responses. RNA, a delivery form of nucleotides, and ribonucleotides were used in these studies. The mechanism of the immune-enhancing activity of nucleic acids/nucleotides is not clear. |
| Targets: | Cyclic AMP-responsive element-binding protein 1 activator; DNA component of; cAMP-specific 3',5'-cyclic phosphodiesterase 4B product of; Glycogen phosphorylase, liver form activator; 5'-AMP-activated protein kinase subunit beta-1 activator; Histidine triad nucleotide-binding protein 1 product of; cAMP-specific 3',5'-cyclic phosphodiesterase 4D product of; Acetyl-coenzyme A synthetase, cytoplasmic product of; 5'-AMP-activated protein kinase catalytic subunit alpha-1 activator; Adenylate cyclase type 1 product of; Long-chain-fatty-acid--CoA ligase 1 product of; Fructose-1,6-bisphosphatase 1 antagonist; Adenosine kinase product of; 5'-AMP-activated protein kinase activator |
| Inclusion Criteria: | Target associated |
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
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| Diseases ID | DO ID | Disease Name | Definition | Class | |
|---|---|---|---|---|---|
| I02 | 5113 | Nutritional deficiency disease | A nutrition disease that is characterized by deficiency of a nutritional element, such as a vitamin, mineral, carbohydrate, protein, fat, or general energy content. https://medlineplus.gov/malnutrition.html | disease of metabolism/acquired metabolic disease/nutrition disease | Details |