Repositioning Candidate Details
| Candidate ID: | R0047 |
| Source ID: | DB00139 |
| Source Type: | approved; nutraceutical |
| Compound Type: | small molecule |
| Compound Name: | Succinic acid |
| Synonyms: | 1,2-ethanedicarboxylic acid; Amber acid; Asuccin; Butanedioic acid; Butanedionic acid; Dihydrofumaric acid; Ethylenesuccinic acid; Spirit of amber; Succinic acid |
| Molecular Formula: | C4H6O4 |
| SMILES: | OC(=O)CCC(O)=O |
| Structure: |
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| DrugBank Description: | A water-soluble, colorless crystal with an acid taste that is used as a chemical intermediate, in medicine, the manufacture of lacquers, and to make perfume esters. It is also used in foods as a sequestrant, buffer, and a neutralizing agent. (Hawley's Condensed Chemical Dictionary, 12th ed, p1099; McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1851) |
| CAS Number: | 110-15-6 |
| Molecular Weight: | 118.088 |
| DrugBank Indication: | For nutritional supplementation, also for treating dietary shortage or imbalance |
| DrugBank Pharmacology: | -- |
| DrugBank MoA: | Succinate is an essential component of the Krebs or citric acid cycle and serves an electron donor in the production of fumaric acid and FADH2. It also has been shown to be a good "natural" antibiotic because of its relative acidic or caustic nature (high concentrations can even cause burns). Succinate supplements have been shown to help reduce the effects of hangovers by activating the degradation of acetaldehyde - a toxic byproduct of alcohol metabolism - into CO2 and H2O through aerobic metabolism. Succinic acid has been shown to stimulate neural system recovery and bolster the immune system. Claims have also been made that it boosts awareness, concentration and reflexes. |
| Targets: | Succinate receptor 1; Succinate-semialdehyde dehydrogenase, mitochondrial inhibitor |
| Inclusion Criteria: | Indication associated |
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
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| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
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| Diseases ID | DO ID | Disease Name | Definition | Class | |
|---|---|---|---|---|---|
| I02 | 5113 | Nutritional deficiency disease | A nutrition disease that is characterized by deficiency of a nutritional element, such as a vitamin, mineral, carbohydrate, protein, fat, or general energy content. https://medlineplus.gov/malnutrition.html | disease of metabolism/acquired metabolic disease/nutrition disease | Details |