Repositioning Candidate Details
| Candidate ID: | R0489 |
| Source ID: | DB01321 |
| Source Type: | investigational |
| Compound Type: | small molecule |
| Compound Name: | Josamycin |
| Synonyms: | JM; Josamycin; Kitasamycin A3; Leucomycin A3; leucomycin V 3-acetate 4B-(3-methylbutanoate); leucomycin V 3-acetate 4β-(3-methylbutanoate); Turimycin A5 |
| Molecular Formula: | C42H69NO15 |
| SMILES: | CO[C@H]1[C@@H](CC(=O)O[C@H](C)C\C=C\C=C\[C@H](O)[C@H](C)C[C@H](CC=O)[C@@H]1O[C@@H]1O[C@H](C)[C@@H](O[C@H]2C[C@@](C)(O)[C@@H](OC(=O)CC(C)C)[C@H](C)O2)[C@@H]([C@H]1O)N(C)C)OC(C)=O |
| Structure: |
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| DrugBank Description: | A macrolide antibiotic from Streptomyces narbonensis. The drug has antimicrobial activity against a wide spectrum of pathogens. |
| CAS Number: | 16846-24-5 |
| Molecular Weight: | 827.995 |
| DrugBank Indication: | For the treatment of bacterial infections. |
| DrugBank Pharmacology: | Josamycin is a macrolide antibiotic from <i>Streptomyces narbonensis</i>. The drug has antimicrobial activity against a wide spectrum of pathogens. |
| DrugBank MoA: | The mechanism of action of macrolides such as Josamycin is via inhibition of bacterial protein biosynthesis by binding reversibly to the subunit 50S of the bacterial ribosome, thereby inhibiting translocation of peptidyl tRNA. This action is mainly bacteriostatic, but can also be bactericidal in high concentrations. Macrolides tend to accumulate within leukocytes, and are therefore actually transported into the site of infection. |
| Targets: | 50S ribosomal protein L4 inhibitor |
| Inclusion Criteria: | Indication associated |
