Repositioning Candidate Details
| Candidate ID: | R0050 |
| Source ID: | DB00147 |
| Source Type: | experimental; nutraceutical |
| Compound Type: | small molecule |
| Compound Name: | Pyridoxal |
| Synonyms: | 2-methyl-3-hydroxy-4-formyl-5-hydroxymethylpyridine; 3-hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinecarboxaldehyde; 3-hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde; 3-hydroxy-5-(hydroxymethyl)-2-methylpyridine-4-carboxaldehyde; Piridoxal; Pyridoxaldehyde |
| Molecular Formula: | C8H9NO3 |
| SMILES: | CC1=NC=C(CO)C(C=O)=C1O |
| Structure: |
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| DrugBank Description: | The 4-carboxyaldehyde form of vitamin B 6 which is converted to pyridoxal phosphate which is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. |
| CAS Number: | 66-72-8 |
| Molecular Weight: | 167.162 |
| DrugBank Indication: | Pyridoxal is one of the natural forms available of vitamin B6, therefore, it is used for nutritional supplementation and for treating dietary shortage or imbalances. |
| DrugBank Pharmacology: | Pyridoxal principally in the form of the coenzyme pyridoxal 5'-phosphate, is involved in a wide range of biochemical reactions, including the metabolism of amino acids and glycogen, the synthesis of nucleic acids, hemogloblin, sphingomyelin and other sphingolipids, and the synthesis of the neurotransmitters serotonin, dopamine, norepinephrine and gamma-aminobutyric acid (GABA). |
| DrugBank MoA: | Pyridoxal is the precursor to pyridoxal phosphate. Pyridoxal 5'-phosphate is involved in a wide range of biochemical reactions, including the metabolism of amino acids and glycogen, the synthesis of nucleic acids, hemogloblin, sphingomyelin and other sphingolipids, and the synthesis of the neurotransmitters serotonin, dopamine, norepinephrine and gamma-aminobutyric acid (GABA). |
| Targets: | Pyridoxal kinase |
| Inclusion Criteria: | Indication associated |
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
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| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
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| Diseases ID | DO ID | Disease Name | Definition | Class | |
|---|---|---|---|---|---|
| I02 | 5113 | Nutritional deficiency disease | A nutrition disease that is characterized by deficiency of a nutritional element, such as a vitamin, mineral, carbohydrate, protein, fat, or general energy content. https://medlineplus.gov/malnutrition.html | disease of metabolism/acquired metabolic disease/nutrition disease | Details |