Repositioning Candidate Details
| Candidate ID: | R0509 |
| Source ID: | DB01390 |
| Source Type: | approved |
| Compound Type: | small molecule |
| Compound Name: | Sodium bicarbonate |
| Synonyms: | Baking soda; Bicarbonate of soda; Carbonic acid monosodium salt; NaHCO3; Sodium acid carbonate; Sodium bicarbonate; Sodium hydrogen carbonate; Sodium hydrogencarbonate |
| Molecular Formula: | CHNaO3 |
| SMILES: | [Na+].OC([O-])=O |
| Structure: |
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| DrugBank Description: | Sodium bicarbonate is a white, crystalline powder that is commonly used as a pH buffering agent, an electrolyte replenisher, systemic alkalizer and in topical cleansing solutions. |
| CAS Number: | 144-55-8 |
| Molecular Weight: | 84.0066 |
| DrugBank Indication: | Sodium bicarbonate is used for the treatment of metabolic acidosis which may occur in severe renal disease, uncontrolled diabetes, circulatory insufficiency due to shock or severe dehydration, extracorporeal circulation of blood, cardiac arrest and severe primary lactic acidosis. Also is indicated in severe diarrhea which is often accompanied by a significant loss of bicarbonate. Further indicated in the treatment of certain drug intoxications, including barbiturates (where dissociation of the barbiturateprotein complex is desired), in poisoning by salicylates or methyl alcohol and in hemolytic reactions requiring alkalinization of the urine to diminish nephrotoxicity of blood pigments. |
| DrugBank Pharmacology: | Intravenous sodium bicarbonate therapy increases plasma bicarbonate, buffers excess hydrogen ion concentration, raises blood pH and reverses the clinical manifestations of acidosis. |
| DrugBank MoA: | Sodium bicarbonate is a systemic alkalizer, which increases plasma bicarbonate, buffers excess hydrogen ion concentration, and raises blood pH, thereby reversing the clinical manifestations of acidosis. It is also a urinary alkalizer, increasing the excretion of free bicarbonate ions in the urine, thus effectively raising the urinary pH. By maintaining an alkaline urine, the actual dissolution of uric acid stones may be accomplished. Sodium bicarbonate acts as an antacid and reacts chemically to neutralize or buffer existing quantities of stomach acid but has no direct effect on its output. This action results in increased pH value of stomach contents, thus providing relief of hyperacidity symptoms. |
| Targets: | Hydrogen ions neutralizer |
| Inclusion Criteria: | Indication associated |
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