Repositioning Candidate Details
| Candidate ID: | R0531 |
| Source ID: | DB01579 |
| Source Type: | approved; illicit |
| Compound Type: | small molecule |
| Compound Name: | Phendimetrazine |
| Synonyms: | (2S,3S)-3,4-dimethyl-2-phenylmorpholine; Phendimetrazine |
| Molecular Formula: | C12H17NO |
| SMILES: | C[C@H]1[C@@H](OCCN1C)C1=CC=CC=C1 |
| Structure: |
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| DrugBank Description: | Phendimetrazine is a weight loss medication. Phendimetrazine is chemically related to amphetamines and is a Schedule III drug under the Convention on Psychotropic Substances and in the US since 1970. |
| CAS Number: | 634-03-7 |
| Molecular Weight: | 191.274 |
| DrugBank Indication: | Used in the management of exogenous obesity as a short term adjunct (a few weeks) in a regimen of weight reduction based on caloric restriction. |
| DrugBank Pharmacology: | Phendimetrazine is a phenylalkylamine sympathomimetic amine with pharmacological activity similar to the prototype drugs of this class used in obesity, the amphetamines. Actions include central nervous system stimulation and elevation of blood pressure. Tachyphylaxis and tolerance has been demonstrated with all drugs of this class in which these phenomena have been looked for. Drugs of this class used in obesity are commonly known as ''anorectics or anorexigenics." It has not been established, however, that the action of such drugs in treating obesity is primarily one of appetite suppression. Other central nervous system actions or metabolic effects, may be involved. |
| DrugBank MoA: | Phendimetrazine may act in a similar way to amphetamines in that it activates the alpha-adrenergic system to induce an appetite suppressive and metabolic increase effect. The drug also acts as a norepinephrine-dopamine releasing agent (NDRA). It can bind to and reverse the NET. |
| Targets: | Alpha-1A adrenergic receptor agonist; Sodium-dependent noradrenaline transporter negative modulator; Alpha-1B adrenergic receptor agonist |
| Inclusion Criteria: | Therapeutic strategy associated |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Diseases ID | DO ID | Disease Name | Definition | Class | |
|---|---|---|---|---|---|
| I14 | 9970 | Obesity | An overnutrition that is characterized by excess body fat, traditionally defined as an elevated ratio of weight to height (specifically 30 kilograms per meter squared), has_material_basis_in a multifactorial etiology related to excess nutrition intake, decreased caloric utilization, and genetic susceptibility, and possibly medications and certain disorders of metabolism, endocrine function, and mental illness. https://en.wikipedia.org/wiki/Obesity | disease of metabolism/acquired metabolic disease/ nutrition disease/overnutrition | Details |