Repositioning Candidate Details
| Candidate ID: | R0545 |
| Source ID: | DB01612 |
| Source Type: | approved |
| Compound Type: | small molecule |
| Compound Name: | Amyl Nitrite |
| Synonyms: | 1-nitropentane; n-Amyl nitrite; n-pentyl nitrite; Nitramyl; pentyl nitrite |
| Molecular Formula: | C5H11NO2 |
| SMILES: | CCCCCON=O |
| Structure: |
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| DrugBank Description: | Amyl Nitrite is an antihypertensive medicine. Amyl nitrite is employed medically to treat heart diseases such as angina and to treat cyanide poisoning. Its use as a prescription medicine comes from its ability to lower blood pressure. As an inhalant, it also has psychoactive effect which has led to illegal drug use. |
| CAS Number: | 8017-89-8 |
| Molecular Weight: | 117.1463 |
| DrugBank Indication: | For the rapid relief of angina pectoris. |
| DrugBank Pharmacology: | Amyl nitrite, in common with other alkyl nitrites, is a potent vasodilator. It expands blood vessels, resulting in lowering of the blood pressure. Alkyl nitrite functions as a source of nitric oxide, which signals for relaxation of the involuntary muscles. Adverse effects are related to this pharmacological activity and include hypotension, headache, flushing of the face, tachycardia, dizziness, and relaxation of involuntary muscles, especially the blood vessel walls and the anal sphincter. |
| DrugBank MoA: | Amyl nitrite's antianginal action is thought to be the result of a reduction in systemic and pulmonary arterial pressure (afterload) and decreased cardiac output because of peripheral vasodilation, rather than coronary artery dilation. Amyl nitrite is a source of nitric oxide, which accounts for the mechanism described above. As an antidote (to cyanide poisoning), amyl nitrite promotes formation of methemoglobin, which combines with cyanide to form nontoxic cyanmethemoglobin. |
| Targets: | Atrial natriuretic peptide receptor 1 agonist |
| Inclusion Criteria: | Indication associated |
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
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| Diseases ID | DO ID | Disease Name | Definition | Class | |
|---|---|---|---|---|---|
| I08 | 114 | Cardiovascular system disease | A disease of anatomical entity which occurs in the blood, heart, blood vessels or the lymphatic system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells or lymph to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis. http://en.wikipedia.org/wiki/Circulatory_system | disease of anatomical entity | Details |