Repositioning Candidate Details
| Candidate ID: | R0547 |
| Source ID: | DB01625 |
| Source Type: | approved; vet_approved |
| Compound Type: | small molecule |
| Compound Name: | Isopropamide |
| Synonyms: | Isopropamide |
| Molecular Formula: | C23H33N2O |
| SMILES: | CC(C)[N+](C)(CCC(C(N)=O)(C1=CC=CC=C1)C1=CC=CC=C1)C(C)C |
| Structure: |
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| DrugBank Description: | Isopropamide iodide is a long-acting quaternary anticholinergic drug. It is used in the treatment of peptic ulcer and other gastrointestinal disorders marked by hyperacidity and hypermotility. |
| CAS Number: | 7492-32-2 |
| Molecular Weight: | 353.5209 |
| DrugBank Indication: | For the treatment of a wide range of gastrointestinal disorders, including such conditions as peptic ulcer, gastritis, hyperchlorhydria, functional diarrhea, irritable or spastic colon, pyloroduodenal irritability, pylorospasm, acute nonspecific gastroenteritis, biliary dyskinesia and chronic cholelithiasis, duodenitis, gastrointestinal spasm; it may also be used to treat genitourinary spasm. |
| DrugBank Pharmacology: | Isopropamide is a long-acting quaternary anticholinergic drug. It is used in the treatment of peptic ulcer and other gastrointestinal disorders marked by hyperacidity and hypermotility. |
| DrugBank MoA: | Anticholinergics are a class of medications that inhibit parasympathetic nerve impulses by selectively blocking the binding of the neurotransmitter acetylcholine to its receptor in nerve cells. The nerve fibers of the parasympathetic system are responsible for the involuntary movements of smooth muscles present in the gastrointestinal tract. Inhibition here decreases acidity and motility, aiding in the treatment of gastrointestinal disorders. |
| Targets: | Muscarinic acetylcholine receptor M3 antagonist; Muscarinic acetylcholine receptor M4 antagonist |
| Inclusion Criteria: | Indication associated |
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| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
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