Associated Disease Details
| Disease ID: | I03 |
| DO ID: | 10211 |
| Disease Name: | Cholelithiasis |
| Definition: | cholelithiasis |
| Synonyms: | Cholelithiasis |
| Class: | disease of anatomical entity/gastrointestinal system disease/gallbladder disease |
| Related Drugs: | Ursodeoxycholic acid |
| Mechanism: | Gatients with metabolic risk factors and cholelithiasis suffer significantly more often from NAFLD compared with the reference group. Cholelithiasis represents an independent risk factor of NAFLD in addition to metabolic risk factors and could be regarded as an additional risk factor of liver damage in patients with NAFLD. Furthermore, NAFLD is an independent risk factor for cholelithiasis and might represent a pathogenetic link between the metabolic syndrome and cholelithiasis. |
| Reference (PMIDs): | 22182015 |
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| D133 | Fenofibrate | Chemical drug | DB01039 | PPARA agonist; NR1I2 partial agonist | Anti-inflammatory | Under clinical trials | Details |
| D406 | Gemfibrozil | Chemical drug | DB01241 | PPARA agonist; SLCO1B1 inhibitor; SLC22A8 inhibitor; SLCO2B1 inhibitor; SLCO1B3 inhibitor | Hypolipidemic drug | Under investigation | Details |
| Article ID | PMID | Source | Title | |
|---|---|---|---|---|
| A00272 | 35158328 | J Physiol Pharmacol | Current approach to hepatobiliary manifestations in inflammatory bowel disease. | Details |
| A00468 | 35070000 | World J Hepatol | Liver manifestations and complications in inflammatory bowel disease: A review. | Details |
| A00912 | 34932603 | PLoS One | Abdominal pain and cirrhosis at diagnosis of hemochromatosis: Analysis of 219 referred probands with HFE p.C282Y homozygosity and a literature review. | Details |
| A01030 | 34896638 | Ann Hepatol | Laparoscopic cholecystectomy: Histopathological analysis of metabolic associated fatty liver disease and fibrosis. | Details |
| A01197 | 34830641 | J Clin Med | Liver Pathology in Children with Diagnosed Inflammatory Bowel Disease-A Single Center Experience. | Details |
| A03311 | 34049413 | Exp Clin Endocrinol Diabetes | Thyroid Hormone Deficiency Modifies Hepatic Lipid Droplet Morphology and Molecular Properties in Lithogenic-Diet Supplemented Mice. | Details |
| A04778 | 33509389 | Lancet Digit Health | Screening and identifying hepatobiliary diseases through deep learning using ocular images: a prospective, multicentre study. | Details |
| A05176 | 33346459 | Ter Arkh | [Clinical features of the comorbid course of non-alcoholic fatty liver disease and gallstone disease]. | Details |
| A05665 | 33167521 | Int J Mol Sci | Roles of Adipokines in Digestive Diseases: Markers of Inflammation, Metabolic Alteration and Disease Progression. | Details |
| A06051 | 33027714 | Pharmacol Res | FATP2-targeted therapies - A role beyond fatty liver disease. | Details |
| A06250 | 32952345 | World J Gastroenterol | Liver fat accumulation measured by high-speed T2-corrected multi-echo magnetic resonance spectroscopy can predict risk of cholelithiasis. | Details |
| A06581 | 32821071 | World J Gastroenterol | Helicobacter pylori infection: Beyond gastric manifestations. | Details |
| A07151 | 32598718 | Ter Arkh | [Features of the course of gallstone disease in patients with non-alcoholic fatty liver disease]. | Details |
| A07913 | 32312927 | Pol Przegl Chir | Prevalence of non-alcoholic fatty liver disease and hypercholesterolemia in patients with gallstone disease undergoing laparoscopic cholecystectomy. | Details |
| A08207 | 32205261 | J Ethnopharmacol | Schaftoside alleviates HFD-induced hepatic lipid accumulation in mice via upregulating farnesoid X receptor. | Details |
| A08241 | 32190771 | Transl Gastroenterol Hepatol | Cholecystectomy does not worsen progression or outcomes in non-alcoholic fatty liver disease. | Details |
| A09357 | 31779732 | J Helminthol | Association between eosinophil count and cholelithiasis among a population with Clonorchis sinensis infection in Foshan City, China. | Details |
| A10596 | 31277096 | Medicine (Baltimore) | The grade of nonalcoholic fatty liver disease is an independent risk factor for gallstone disease: An observational Study. | Details |
| A10979 | 31094171 | Ter Arkh | Comparative analysis of bile acid spectrum in non-alcoholic fatty liver disease and cholelithiasis. | Details |
| A11573 | 30834274 | Biomed Res Int | Frequency of Hepatobiliary Manifestations and Concomitant Liver Disease in Inflammatory Bowel Disease Patients. | Details |