Repositioning Candidate Details
| Candidate ID: | R0557 |
| Source ID: | DB01992 |
| Source Type: | investigational; nutraceutical |
| Compound Type: | small molecule |
| Compound Name: | Coenzyme A |
| Synonyms: | 3'-phosphoadenosine-(5')diphospho(4')pantatheine; CoA; CoA-SH; CoASH; HSCoA |
| Molecular Formula: | C21H36N7O16P3S |
| SMILES: | CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)[C@@H](O)C(=O)NCCC(=O)NCCS |
| Structure: |
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| DrugBank Description: | Coenzyme A (CoA, CoASH, or HSCoA) is a coenzyme, well known for it's role in the synthesis and oxidation of fatty acids, and the oxidation of pyruvate in the citric acid cycle. All genomes sequenced to date encode enzymes that use coenzyme A as a substrate, and around 4% of cellular enzymes use it, or a thioester form of it, as a substrate. It is used as a supplement for the hypothetical treatment of acne. |
| CAS Number: | 85-61-0 |
| Molecular Weight: | 767.534 |
| DrugBank Indication: | -- |
| DrugBank Pharmacology: | -- |
| DrugBank MoA: | -- |
| Targets: | Acetyl-coenzyme A synthetase; Acyl-CoA-binding protein; Formyl-coenzyme A transferase; Carnitine O-acetyltransferase; Crotonobetainyl-CoA:carnitine CoA-transferase; Formate acetyltransferase 1; Malate synthase G; 3-hydroxy-3-methylglutaryl-coenzyme A reductase; Phosphopantetheine adenylyltransferase; Holo-[acyl-carrier-protein] synthase; Protease synthase and sporulation negative regulatory protein PAI 1; Gentamicin 3'-acetyltransferase; Galactoside O-acetyltransferase; 3-hydroxy-3-methylglutaryl-coenzyme A reductase; Fatty acid metabolism regulator protein; Histone acetyltransferase KAT5; 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Acetyl-CoA acetyltransferase, cytosolic; Acetyl-CoA acetyltransferase; Streptogramin A acetyltransferase; Citrate synthase, mitochondrial; 3-oxoacyl-[acyl-carrier-protein] synthase 3; Formyl-coenzyme A transferase; Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex; Pantothenate kinase; Acetyl transferase; Uncharacterized N-acetyltransferase YvbK; Aminoglycoside N(6')-acetyltransferase type 1; Acyl-CoA hydrolase; Uncharacterized acyl-CoA thioester hydrolase HI_0827; 3-oxoacyl-[acyl-carrier-protein] synthase 3; Mycothiol acetyltransferase; Histone acetyltransferase KAT2A; Acyl-CoA hydrolase; Histone acetyltransferase KAT2B; 1,4-Dihydroxy-2-naphthoyl-CoA synthase; Citrate synthase; Aminoglycoside 2'-N-acetyltransferase; Aac(6')-Ii protein; 4'-phosphopantetheinyl transferase sfp; Uncharacterized protein; Serine acetyltransferase; Citrate synthase; 4-hydroxybenzoyl-CoA thioesterase; Bifunctional protein GlmU |
| Inclusion Criteria: | Target associated |
