Therapeutic Target Details
| Target ID: | T15 |
| Target Name: | 3-hydroxy-3-methylglutaryl-coenzyme A reductase |
| Synonyms: | HMG-CoA reductase; HMGCR |
| GENE: | HMGCR |
| Action: | inhibitor |
| Class: | Enzyme |
| UniProtKB ID: | P04035 |
| Entry Name: | HMDH_HUMAN |
| Related Drugs: | Rosuvastatin; Pitavastatin; Atorvastatin |
| Mechanism: | Dicer1/miR-29/HMGCR axis contributes to hepatic free cholesterol accumulation in mouse NASH, and miR-29 may serve as an important regulator of hepatic cholesterol homeostasis. Thus, miR-29a could be utilized as a potential therapeutic target for the treatment of non-alcoholic fatty liver disease as well as for other liver diseases associated with FC accumulation |
| Reference (PMIDs): | 28112179 |
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| D020 | Atorvastatin | Chemical drug | DB01076 | DPP4 inhibitor; AHR agonist; HDAC2 inhibitor; NR1I3 ligand | Enhance lipid metabolism | Under clinical trials | Details |
| D277 | Pitavastatin | Chemical drug | DB08860 | HMGCR inhibitor | Enhance lipid metabolism | Failed in clinical trials | Details |
| D312 | Rosuvastatin | Chemical drug | DB01098 | HMGCR inhibitor | Enhance lipid metabolism | Under clinical trials | Details |
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria | |
|---|---|---|---|---|---|---|
| R0055 | DB00157 | approved; nutraceutical | small molecule | NADH | Target associated | Details |
| R0062 | DB00175 | approved | small molecule | Pravastatin | Target associated | Details |
| R0088 | DB00227 | approved; investigational | small molecule | Lovastatin | Therapeutic strategy associated | Details |
| R0147 | DB00439 | approved; withdrawn | small molecule | Cerivastatin | Target associated | Details |
| R0227 | DB00641 | approved | small molecule | Simvastatin | Therapeutic strategy associated | Details |
| R0402 | DB01095 | approved | small molecule | Fluvastatin | Target associated | Details |
| R0557 | DB01992 | investigational; nutraceutical | small molecule | Coenzyme A | Target associated | Details |
| R0576 | DB03169 | experimental | small molecule | (S)-Hmg-Coa | Target associated | Details |
| R0584 | DB03461 | experimental | small molecule | Nicotinamide adenine dinucleotide phosphate | Target associated | Details |
| R0587 | DB03518 | experimental | small molecule | Mevalonic acid | Target associated | Details |
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| B000001 | CHEMBL10 | Small molecule | SB-203580 | 377.44 | C21H16FN3OS | NEUTRAL | Details |
| B000003 | CHEMBL100165 | Small molecule | -- | 440.49 | C24H30FNaO5 | ACID | Details |
| B000014 | CHEMBL1006 | Small molecule | AMIFOSTINE | 214.23 | C5H15N2O3PS | ZWITTERION | Details |
| B000021 | CHEMBL1009 | Small molecule | LEVODOPA | 197.19 | C9H11NO4 | ZWITTERION | Details |
| B000025 | CHEMBL101 | Small molecule | PHENYLBUTAZONE | 308.38 | C19H20N2O2 | ACID | Details |
| B000032 | CHEMBL101168 | Small molecule | -- | 134.14 | C6H6N4 | NEUTRAL | Details |
| B000045 | CHEMBL101497 | Small molecule | -- | 449.45 | C24H25FNNaO5 | ACID | Details |
| B000049 | CHEMBL1016 | Small molecule | CANDESARTAN | 440.46 | C24H20N6O3 | ACID | Details |
| B000050 | CHEMBL101600 | Small molecule | -- | 499.62 | C27H42NNaO6 | ACID | Details |
| B000061 | CHEMBL101824 | Small molecule | -- | 380.91 | C21H29ClO4 | NEUTRAL | Details |
| Article ID | PMID | Source | Title | |
|---|---|---|---|---|
| A01861 | 34585409 | J Food Biochem | Crataegus aronia prevents high-fat diet-induced hepatic steatosis in rats by activating AMPK-induced suppression of SREBP1 and activation of PPARα. | Details |
| A05674 | 33164398 | Zhongguo Zhong Yao Za Zhi | [Mechanism of Alisma orientale in treating nonalcoholic fatty liver disease]. | Details |
| A07515 | 32461046 | Clin Chim Acta | Emerging role of Insig-1 in lipid metabolism and lipid disorders. | Details |
| A15293 | 28982243 | J Agric Food Chem | Solanum nigrum Polyphenol Extracts Inhibit Hepatic Inflammation, Oxidative Stress, and Lipogenesis in High-Fat-Diet-Treated Mice. | Details |
| A17911 | 27483220 | Molecules | Efficacy of Acetylshikonin in Preventing Obesity and Hepatic Steatosis in db/db Mice. | Details |
| A18856 | 26900108 | J Agric Food Chem | Ginger Essential Oil Ameliorates Hepatic Injury and Lipid Accumulation in High Fat Diet-Induced Nonalcoholic Fatty Liver Disease. | Details |
| A22040 | 24857364 | J Agric Food Chem | Garlic essential oil protects against obesity-triggered nonalcoholic fatty liver disease through modulation of lipid metabolism and oxidative stress. | Details |
| A24852 | 22432744 | J Gastroenterol Hepatol | Atorvastatin protects obese mice against hepatic ischemia-reperfusion injury by Toll-like receptor-4 suppression and endothelial nitric oxide synthase activation. | Details |
| A26714 | 19913842 | Metabolism | Analysis of transcriptome and metabolome profiles alterations in fatty liver induced by high-fat diet in rat. | Details |
| A44033 | 30078674 | Biochem Biophys Res Commun | Fluvastatin activates sirtuin 6 to regulate sterol regulatory element-binding proteins and AMP-activated protein kinase in HepG2 cells. | Details |
| A47266 | 20041784 | J Med Food | Protective effect of Codonopsis lanceolata root extract against alcoholic fatty liver in the rat. | Details |
| A47864 | 30660733 | Gastroenterology | Effects of Hypercholesterolemia and Statin Exposure on Survival in a Large National Cohort of Patients With Cirrhosis. | Details |