Repositioning Candidate Details
| Candidate ID: | R0568 |
| Source ID: | DB02659 |
| Source Type: | approved |
| Compound Type: | small molecule |
| Compound Name: | Cholic Acid |
| Synonyms: | Cholic Acid |
| Molecular Formula: | C24H40O5 |
| SMILES: | [H][C@@](C)(CCC(O)=O)[C@@]1([H])CC[C@@]2([H])[C@]3([H])[C@]([H])(O)C[C@]4([H])C[C@]([H])(O)CC[C@]4(C)[C@@]3([H])C[C@]([H])(O)[C@]12C |
| Structure: |
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| DrugBank Description: | A major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion. Cholic acid, formulated as Cholbam capsules, is approved by the United States Food and Drug Administration as a treatment for children and adults with bile acid synthesis disorders due to single enzyme defects, and for peroxisomal disorders (such as Zellweger syndrome). |
| CAS Number: | 81-25-4 |
| Molecular Weight: | 408.5714 |
| DrugBank Indication: | Oral cholic acid is indicated for: treatment of bile acid synthesis disorders due to single enzyme defects; and as adjunctive treatment of peroxisomal disorders including Zellweger spectrum disorders in patients who exhibit manifestations of liver disease, steatorrhea or complications from decreased fat soluble vitamin absorption. |
| DrugBank Pharmacology: | -- |
| DrugBank MoA: | -- |
| Targets: | Ferrochelatase, mitochondrial; Alcohol dehydrogenase 1C; Estrogen-related receptor gamma; Gastrotropin; Cytochrome c oxidase subunit 4 isoform 1, mitochondrial; Cytochrome c oxidase subunit 1; Cytochrome c oxidase subunit 2; Cytochrome c oxidase subunit 3; Cytochrome c oxidase subunit 5A, mitochondrial; Cytochrome c oxidase subunit 5B, mitochondrial; Cytochrome c oxidase subunit 6C; Cytochrome c oxidase subunit 7B, mitochondrial; Cytochrome c oxidase subunit 7C, mitochondrial; Cytochrome c oxidase subunit 8A, mitochondrial; Cytochrome c oxidase subunit 6A2, mitochondrial; Cytochrome c oxidase subunit 6B1; Cytochrome c oxidase subunit 7A1, mitochondrial; Phospholipase A2; Liver carboxylesterase 1; Ferrochelatase; Choloylglycine hydrolase; Bile acid receptor; G-protein coupled bile acid receptor 1 |
| Inclusion Criteria: | Target associated |
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| Diseases ID | DO ID | Disease Name | Definition | Class |
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