Repositioning Candidate Details
| Candidate ID: | R0584 |
| Source ID: | DB03461 |
| Source Type: | experimental |
| Compound Type: | small molecule |
| Compound Name: | Nicotinamide adenine dinucleotide phosphate |
| Synonyms: | Codehydrase II; Codehydrogenase II; Coenzyme II; Triphosphopyridine nucleotide |
| Molecular Formula: | C21H28N7O17P3 |
| SMILES: | NC(=O)C1=CC=C[N+](=C1)[C@@H]1O[C@H](COP([O-])(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O |
| Structure: |
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| DrugBank Description: | Nicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed) |
| CAS Number: | 53-59-8 |
| Molecular Weight: | 743.405 |
| DrugBank Indication: | -- |
| DrugBank Pharmacology: | -- |
| DrugBank MoA: | -- |
| Targets: | Alcohol dehydrogenase 1B; NADPH--cytochrome P450 reductase; Shikimate dehydrogenase; NADP-dependent isopropanol dehydrogenase; GDP-L-fucose synthase; Aspartate-semialdehyde dehydrogenase; 2,4-dienoyl-CoA reductase [NADPH]; NADP-dependent malic enzyme; NAD(P) transhydrogenase subunit beta; 3-oxoacyl-[acyl-carrier-protein] reductase FabG; Isocitrate dehydrogenase [NADP]; Aldose reductase; Glucose-6-phosphate 1-dehydrogenase; Aldo-keto reductase family 1 member C2; Estradiol 17-beta-dehydrogenase 1; NAD(P) transhydrogenase, mitochondrial; Corticosteroid 11-beta-dehydrogenase isozyme 1; Sepiapterin reductase; Pteridine reductase 1; L-xylulose reductase; Isocitrate dehydrogenase [NADP] cytoplasmic; Dihydrofolate reductase; Aldo-keto reductase family 1 member C1; Nitric oxide synthase, brain; Glucose-6-phosphate 1-dehydrogenase; Dihydrofolate reductase; ADP-L-glycero-D-manno-heptose-6-epimerase; C-1-tetrahydrofolate synthase, cytoplasmic; Aldo-keto reductase family 1 member C3; Flavin reductase (NADPH); Isocitrate dehydrogenase [NADP]; Dihydrofolate reductase; Quinone oxidoreductase; Dehydrogenase/reductase SDR family member 11; 3-hydroxy-3-methylglutaryl-coenzyme A reductase; Malate dehydrogenase, cytoplasmic; Oxidoreductase YdhF; Putative pteridine reductase 2; Estradiol 17-beta-dehydrogenase 8; Alcohol dehydrogenase [NADP(+)]; Putative ketoacyl reductase; 2,4-dienoyl-CoA reductase, mitochondrial; Oxidoreductase, short chain dehydrogenase/reductase family; Prostaglandin F synthase; General stress protein 69; Ferredoxin--NADP reductase; Bifunctional protein MdtA; Alcohol dehydrogenase; NADPH:adrenodoxin oxidoreductase, mitochondrial; Ferredoxin--NADP reductase; 2,5-diketo-D-gluconic acid reductase A; Protein IolS; NADP-dependent glyceraldehyde-3-phosphate dehydrogenase; Prostaglandin reductase 1; Sulfite reductase [NADPH] flavoprotein alpha-component; Aldo-keto reductase family 1 member B10; Alcohol dehydrogenase (NADP(+)); NADP-dependent fatty aldehyde dehydrogenase; Putative dehydrogenase/reductase SDR family member 4-like 2; Aldehyde reductase |
| Inclusion Criteria: | Target associated |
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