Repositioning Candidate Details
| Candidate ID: | R0632 |
| Source ID: | DB04871 |
| Source Type: | approved |
| Compound Type: | small molecule |
| Compound Name: | Lorcaserin |
| Synonyms: | Lorcaserin; Lorqess |
| Molecular Formula: | C11H14ClN |
| SMILES: | C[C@H]1CNCCC2=CC=C(Cl)C=C12 |
| Structure: |
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| DrugBank Description: | Lorcaserin (previously APD-356), a highly selective 5HT2C receptor agonist, is used for the treatment of obesity. It has been shown to reduce body weight and food intake in animal models of obesity, and it is thought that targeting the 5HT2C receptor may alter body weight by regulating satiety. Lorcaserin is marketed as a salt form called Belviq, which is lorcaserin hydrochloride. |
| CAS Number: | 616202-92-7 |
| Molecular Weight: | 195.69 |
| DrugBank Indication: | For the treatment of obesity, as an adjunct to a reduced-calorie diet and increased physical activity. |
| DrugBank Pharmacology: | Lorcaserin produced a dose-dependent weight loss over a 12-week period by promoting satiety and decreasing food consumption. |
| DrugBank MoA: | Although the exact mechanism is unknown, it is believed to involve the selective activation of 5-HT2C receptors in the anorexigenic pro-opiomelanocortin neurons in the arcuate nucleus of the hypothalamus. This results in decreased food intake and satiety by promoting the release of alpha-melanocortin stimulating hormone, which acts on melanocortin-4 receptors. |
| Targets: | 5-hydroxytryptamine receptor 2C |
| Inclusion Criteria: | Therapeutic strategy associated |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Diseases ID | DO ID | Disease Name | Definition | Class | |
|---|---|---|---|---|---|
| I14 | 9970 | Obesity | An overnutrition that is characterized by excess body fat, traditionally defined as an elevated ratio of weight to height (specifically 30 kilograms per meter squared), has_material_basis_in a multifactorial etiology related to excess nutrition intake, decreased caloric utilization, and genetic susceptibility, and possibly medications and certain disorders of metabolism, endocrine function, and mental illness. https://en.wikipedia.org/wiki/Obesity | disease of metabolism/acquired metabolic disease/ nutrition disease/overnutrition | Details |