Repositioning Candidate Details
| Candidate ID: | R0787 |
| Source ID: | DB05412 |
| Source Type: | investigational |
| Compound Type: | small molecule |
| Compound Name: | Talmapimod |
| Synonyms: | Talmapimod |
| Molecular Formula: | C27H30ClFN4O3 |
| SMILES: | [H][C@]1(C)CN(C(=O)C2=C(Cl)C=C3N(C)C=C(C(=O)C(=O)N(C)C)C3=C2)[C@]([H])(C)CN1CC1=CC=C(F)C=C1 |
| Structure: |
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| DrugBank Description: | Talmapimod is the first-generation oral p38 MAP kinase inhibitor developed by Scios. It has shown to be effective to cure inflammatory diseases such as Rheumatoid Arthritis. |
| CAS Number: | 309913-83-5 |
| Molecular Weight: | 513.004 |
| DrugBank Indication: | Investigated for use/treatment in pain (acute or chronic) and rheumatoid arthritis. |
| DrugBank Pharmacology: | -- |
| DrugBank MoA: | SCIO-469 inhibits p38 kinase, a stimulatory modulator of pro-inflammatory factors including tumor necrosis factor-alpha (TNFa), interleukin-1 (IL-1), and cyclooxygenase-2 (COX-2), all of which are known to contribute to both symptoms and disease progression in patients with Rheumatoid Arthritis (RA). Existing protein-based products that antagonize TNFa have been shown to markedly relieve the symptoms and retard the progression of RA. It also has the potential for additional benefits associated with its inhibition of IL-1 and COX-2. |
| Targets: | Mitogen-activated protein kinase 14; Tumor necrosis factor; Interleukin-1 beta; Cytochrome c oxidase subunit 2 |
| Inclusion Criteria: | Therapeutic strategy associated |
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs | |
|---|---|---|---|---|---|
| S05 | Anti-inflammatory | inflammatory | Bile acid; TNF-a inhibitor; Dual PPAR-α and -δ agonists; Toll-Like Receptor; (TLR)-4 antagonist; Caspase inhibitor; ASK-1 inhibitor | Ursodeoxycholic Acid; Pentoxifylline; Elafibranor; JKB-121; Emricasan; Selonsertib; | Details |
| Diseases ID | DO ID | Disease Name | Definition | Class | |
|---|---|---|---|---|---|
| I15 | 1290 | Bone disease | A connective tissue disease that affects the structure or development of bone or causes an impairment of normal bone function. http://en.wikipedia.org/wiki/Bone_disease | disease of anatomical entity/ musculoskeletal system disease/connective tissue disease | Details |