Repositioning Candidate Details

Candidate ID: R0809
Source ID: DB05470
Source Type: investigational
Compound Type: small molecule
Compound Name: VX-702
Synonyms: --
Molecular Formula: C19H12F4N4O2
SMILES: NC(=O)N(C1=CC=C(C(N)=O)C(=N1)C1=CC=C(F)C=C1F)C1=C(F)C=CC=C1F
Structure:
DrugBank Description: VX-702 is a small molecule investigational oral anti-cytokine therapy for treatment of inflammatory diseases, specifically rheumatoid arthritis (RA). It acts as a p38 MAP kinase inhibitor. In the future, VX-702 may be investigated for combination with methotrexate, a commonly used therapy for RA.
CAS Number: 745833-23-2
Molecular Weight: 404.325
DrugBank Indication: Investigated for use/treatment in coronary artery disease, inflammatory disorders (unspecified), and rheumatoid arthritis.
DrugBank Pharmacology: VX-703 is an anti-cytokine therapy in which p38 MAP kinase inhibitor effectively inhibits LPS-stimulated TNF||, IL-6 and IL-1|| production.
DrugBank MoA: This p38 MAP kinase inhibitor effectively inhibits LPS-stimulated TNF||, IL-6 and IL-1|| production.
Targets: Mitogen-activated protein kinase 14; Tumor necrosis factor; Interleukin-1 beta; Interleukin-6
Inclusion Criteria: Target associated

Strategy ID Strategy Synonyms Related Targets Related Drugs
S05 Anti-inflammatory inflammatory Bile acid; TNF-a inhibitor; Dual PPAR-α and -δ agonists; Toll-Like Receptor; (TLR)-4 antagonist; Caspase inhibitor; ASK-1 inhibitor Ursodeoxycholic Acid; Pentoxifylline; Elafibranor; JKB-121; Emricasan; Selonsertib; Details

Target ID Target Name GENE Action Class UniProtKB ID Entry Name
T08 Tumor necrosis factor TNF inhibitor Cytokine P01375 TNFA_HUMAN Details

Diseases ID DO ID Disease Name Definition Class
I15 1290 Bone disease A connective tissue disease that affects the structure or development of bone or causes an impairment of normal bone function. http://en.wikipedia.org/wiki/Bone_disease disease of anatomical entity/ musculoskeletal system disease/connective tissue disease Details