Repositioning Candidate Details

Candidate ID: R0873
Source ID: DB05792
Source Type: investigational
Compound Type: small molecule
Compound Name: Arylacenamide
Synonyms: --
Molecular Formula: C23H35Cl2N
SMILES: Cl.CCN(C\C=C/C1=CC(Cl)=C(C=C1)C1CCCCC1)C1CCCCC1
Structure:
DrugBank Description: Arylacenamide (SR31747) is a peripheral ligand that binds four proteins in human cells, i.e. SRBP-1, -2, HSI and its relative SRBP-2. It is a dual agent with both immunomodulatory and antiproliferative activities.
CAS Number: 132173-07-0
Molecular Weight: 396.437
DrugBank Indication: Investigated for use/treatment in cancer/tumors (unspecified), immunosuppressive, and prostate cancer.
DrugBank Pharmacology: --
DrugBank MoA: SR31747 blocks proliferation of human lymphocytes, modulates the expression of pro- and anti-inflammatory cytokines, and was shown to protect animals in vivo against acute and chronic inflammatory conditions such as acute graft-versus-host reaction, lethality induced by staphylococcal enterotoxin B and lipopolysaccharide or rheumatoid arthritis. Besides these immunomodulatory activities, the molecule also inhibits the proliferation of various tumor cell lines in vitro in a time- and concentration-dependent manner.
Targets: HCG20471, isoform CRA_c
Inclusion Criteria: Therapeutic strategy associated