Repositioning Candidate Details
| Candidate ID: | R0884 |
| Source ID: | DB05843 |
| Source Type: | investigational |
| Compound Type: | small molecule |
| Compound Name: | trans NV-04 |
| Synonyms: | -- |
| Molecular Formula: | -- |
| SMILES: | -- |
| DrugBank Description: | trans NV-04 is a cardiovascular drug which shows a significant reduction in blood pressure and arterial stiffness. |
| CAS Number: | -- |
| Molecular Weight: | |
| DrugBank Indication: | Investigated for use/treatment in cardiovascular disorders and hypertension. |
| DrugBank Pharmacology: | -- |
| DrugBank MoA: | trans-NV-04 promotes blood vessel relaxation, acts as an antioxidant and inhibits smooth muscle cell growth in blood vessels, factors contributing to build up of obstructive vascular plaques or atherosclerosis. |
| Targets: | -- |
| Inclusion Criteria: | Indication associated |
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
|---|
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Diseases ID | DO ID | Disease Name | Definition | Class | |
|---|---|---|---|---|---|
| I12 | 10763 | Hypertension | An artery disease characterized by chronic elevated blood pressure in the arteries. https://en.wikipedia.org/wiki/Hypertension, https://www.ncbi.nlm.nih.gov/pubmed/24352797 | disease of anatomical entity/ cardiovascular system disease/vascular disease/ artery disease | Details |
| I07 | 1936 | Arteriosclerosis | Build-up of fatty material and calcium deposition in the arterial wall resulting in partial or complete occlusion of the arterial lumen.https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C35768 | disease of anatomical entity/cardiovascular system disease/ vascular disease/ artery disease | Details |