Repositioning Candidates
Repositioning candidates for NAFLD are derived from DrugBank which fall into three categories: therapeutic strategy-associated, target-associated, and indication-associated candidates. For each candidate, detailed properties are extracted from DrugBank, and related strategies, target and NAFLD-associated disease in NAFLDkb are presented with knowledge graphs.
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fibrosis59 records.
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria | |
|---|---|---|---|---|---|---|
| R0002 | DB00003 | approved | biotech | Dornase alfa | Therapeutic strategy associated | Details |
| R0046 | DB00138 | approved; nutraceutical | small molecule | Cystine | Therapeutic strategy associated | Details |
| R0056 | DB00159 | approved; nutraceutical | small molecule | Icosapent | Therapeutic strategy associated | Details |
| R0059 | DB00171 | investigational; nutraceutical | small molecule | ATP | Indication associated | Details |
| R0065 | DB00178 | approved | small molecule | Ramipril | Therapeutic strategy associated | Details |
| R0081 | DB00214 | approved | small molecule | Torasemide | Therapeutic strategy associated | Details |
| R0238 | DB00684 | approved; investigational | small molecule | Tobramycin | Indication associated | Details |
| R0239 | DB00688 | approved; investigational | small molecule | Mycophenolate mofetil | Therapeutic strategy associated | Details |
| R0262 | DB00742 | approved; investigational | small molecule | Mannitol | Therapeutic strategy associated | Details |
| R0285 | DB00803 | approved | small molecule | Colistin | Therapeutic strategy associated | Details |
| R0367 | DB01012 | approved | small molecule | Cinacalcet | Therapeutic strategy associated | Details |
| R0371 | DB01016 | approved | small molecule | Glyburide | Indication associated | Details |
| R0385 | DB01050 | approved | small molecule | Ibuprofen | Target associated | Details |
| R0389 | DB01064 | approved; investigational | small molecule | Isoprenaline | Therapeutic strategy associated | Details |
| R0408 | DB01111 | approved; vet_approved | small molecule | Colistimethate | Therapeutic strategy associated | Details |
| R0421 | DB01138 | approved | small molecule | Sulfinpyrazone | Therapeutic strategy associated | Details |
| R0445 | DB01200 | approved; investigational | small molecule | Bromocriptine | Therapeutic strategy associated | Details |
| R0528 | DB01556 | illicit; withdrawn | small molecule | Chlorphentermine | Therapeutic strategy associated | Details |
| R0600 | DB04339 | approved; investigational | small molecule | Carbocisteine | Therapeutic strategy associated | Details |
| R0627 | DB04855 | approved | small molecule | Dronedarone | Therapeutic strategy associated | Details |
| R0658 | DB04951 | approved; investigational | small molecule | Pirfenidone | Therapeutic strategy associated | Details |
| R0670 | DB04987 | investigational | biotech | P113D | Indication associated | Details |
| R0671 | DB04991 | investigational | small molecule | XL784 | Therapeutic strategy associated | Details |
| R0697 | DB05088 | investigational | small molecule | Tetrathiomolybdate | Therapeutic strategy associated | Details |
| R0721 | DB05161 | investigational | small molecule | Elafin | Therapeutic strategy associated | Details |
| R0742 | DB05222 | investigational | biotech | KB001 | Therapeutic strategy associated | Details |
| R0956 | DB06248 | investigational | small molecule | Amelubant | Indication associated | Details |
| R0964 | DB06266 | investigational | small molecule | Lonidamine | Therapeutic strategy associated | Details |
| R0980 | DB06323 | investigational | biotech | AZX-100 | Therapeutic strategy associated | Details |
| R0986 | DB06343 | approved; investigational | biotech | Teprotumumab | Therapeutic strategy associated | Details |
| R1018 | DB06448 | approved; investigational | small molecule | Lonafarnib | Therapeutic strategy associated | Details |
| R1063 | DB06612 | approved; investigational | biotech | Mepolizumab | Therapeutic strategy associated | Details |
| R1080 | DB06689 | approved | small molecule | Ethanolamine oleate | Therapeutic strategy associated | Details |
| R1084 | DB06703 | approved | small molecule | Gadobutrol | Indication associated | Details |
| R1160 | DB08820 | approved | small molecule | Ivacaftor | Therapeutic strategy associated | Details |
| R1164 | DB08834 | experimental; investigational | small molecule | Tauroursodeoxycholic acid | Indication associated | Details |
| R1174 | DB08877 | approved | small molecule | Ruxolitinib | Therapeutic strategy associated | Details |
| R1180 | DB08890 | approved | small molecule | Linaclotide | Therapeutic strategy associated | Details |
| R1188 | DB08931 | approved | small molecule | Riociguat | Therapeutic strategy associated | Details |
| R1214 | DB09079 | approved | small molecule | Nintedanib | Therapeutic strategy associated | Details |
| R1244 | DB09213 | approved; investigational | small molecule | Dexibuprofen | Therapeutic strategy associated | Details |
| R1257 | DB09235 | experimental | small molecule | Efonidipine | Therapeutic strategy associated | Details |
| R1289 | DB09295 | experimental | small molecule | Talniflumate | Indication associated | Details |
| R1316 | DB09532 | approved | biotech | Secretin human | Therapeutic strategy associated | Details |
| R1380 | DB11588 | approved; investigational | small molecule | Carbon monoxide | Therapeutic strategy associated | Details |
| R1394 | DB11712 | approved; investigational | small molecule | Tezacaftor | Therapeutic strategy associated | Details |
| R1437 | DB12169 | approved; investigational | biotech | Tralokinumab | Therapeutic strategy associated | Details |
| R1451 | DB12500 | approved; investigational | small molecule | Fedratinib | Therapeutic strategy associated | Details |
| R1456 | DB12592 | investigational | small molecule | Mosedipimod | Therapeutic strategy associated | Details |
| R1484 | DB13170 | approved; investigational | small molecule | Plecanatide | Therapeutic strategy associated | Details |
| R1485 | DB13174 | experimental | small molecule | Rhein | Therapeutic strategy associated | Details |
| R1503 | DB13931 | approved | small molecule | Netarsudil | Therapeutic strategy associated | Details |
| R1556 | DB15119 | approved; investigational | biotech | Ropeginterferon alfa-2b | Therapeutic strategy associated | Details |
| R1561 | DB15444 | approved; investigational | small molecule | Elexacaftor | Therapeutic strategy associated | Details |
| R1582 | DB15753 | investigational | biotech | Interferon Gamma | Therapeutic strategy associated | Details |
| R1585 | DB15868 | investigational | biotech | Amniotic Epithelial Cells | Therapeutic strategy associated | Details |
| R1589 | DB16157 | investigational | small molecule | Ensifentrine | Therapeutic strategy associated | Details |
| R1590 | DB16165 | approved; investigational | small molecule | Finerenone | Therapeutic strategy associated | Details |
| R1592 | DB16365 | investigational | small molecule | Treamid | Therapeutic strategy associated | Details |