Bioactive Compound Details
| Compound ID: | B132025 |
| Source ID: | CHEMBL376180 |
| Source Type: | Small molecule |
| Compound Name: | AMINOPTERIN |
| Synonyms: | 4-AMINO-PGA|4-AMINOFOLIC ACID|4-Aminopteroic acid|AMINOPTERIN|AMINOTREXATE|Aminopteroylglutamic acid|METHOTREXATE RELATED COMPOUND B|NSC-739 |
| Molecular Formula: | C19H20N8O5 |
| SMILES: | Nc1nc(N)c2nc(CNc3ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc3)cnc2n1 |
| Molecular Species: | ACID |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name | |
|---|---|---|---|---|---|---|---|
| T15 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | HMGCR | inhibitor | Enzyme | P04035 | HMDH_HUMAN | Details |
| T10 | Caspase-1 | CASP1 | inhibitor | Enzyme | P29466 | CASP1_HUMAN | Details |
| T24 | C-C chemokine receptor type 2 | CCR2 | antagonist | GPCR | P41597 | CCR2_HUMAN | Details |
| T25 | C-C chemokine receptor type 5 | CCR5 | antagonist | GPCR | P51681 | CCR5_HUMAN | Details |