Bioactive Compound Details
| Compound ID: | B137592 |
| Source ID: | CHEMBL428647 |
| Source Type: | Small molecule |
| Compound Name: | PACLITAXEL |
| Synonyms: | (-)-PACLITAXEL|ABI-007|ABI-007 COMPONENT PACLITAXEL|Abraxane|BMS 181339-01|BMS-181339-01|CAPXOL|CYCLOPAX|DHP 107|DHP-107|EBETAXEL|EMPAC|ENDOTAG 1|GENAXOL|GENETAXYL|GENEXOL|GENEXOL-PM|INTAXEL|LEP-ETU|MBT 0206|MBT-0206|MITOTAX|NK 105|NK-105|NSC-125973|ONCOGEL|ONXAL|ONXOL|PACITAXEL|PACLIEX|PACLITAXEL|PACLITAXEL (TAXUS CANADENSIS)|PACLITAXOL|PAXENE|PLAXICEL|QW-8184|TAXALBIN|TAXOL|TAXOL 100|TAXOL A|TAXUS|TAXUS LIBERTE|TAXUS STENT|TOCOSOL PACLITAXEL|Taxol|YEWTAXAN |
| Molecular Formula: | C47H51NO14 |
| SMILES: | CC(=O)O[C@H]1C(=O)[C@]2(C)[C@@H](O)C[C@H]3OC[C@@]3(OC(C)=O)[C@H]2[C@H](OC(=O)c2ccccc2)[C@]2(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)c3ccccc3)c3ccccc3)C(C)=C1C2(C)C |
| Molecular Species: | NEUTRAL |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name | |
|---|---|---|---|---|---|---|---|
| T15 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | HMGCR | inhibitor | Enzyme | P04035 | HMDH_HUMAN | Details |
| T10 | Caspase-1 | CASP1 | inhibitor | Enzyme | P29466 | CASP1_HUMAN | Details |
| T24 | C-C chemokine receptor type 2 | CCR2 | antagonist | GPCR | P41597 | CCR2_HUMAN | Details |
| T25 | C-C chemokine receptor type 5 | CCR5 | antagonist | GPCR | P51681 | CCR5_HUMAN | Details |
| T04 | Peroxisome proliferator-activated receptor delta | PPARD | agonist | Nuclear hormone receptor | Q03181 | PPARD_HUMAN | Details |
| T05 | Peroxisome proliferator-activated receptor gamma | PPARG | agonist | Nuclear hormone receptor | P37231 | PPARG_HUMAN | Details |
| T26 | Thyroid hormone receptor beta | THRB | agonist | Nuclear hormone receptor | P10828 | THB_HUMAN | Details |