Bioactive Compound Details
| Compound ID: | B137882 |
| Source ID: | CHEMBL435 |
| Source Type: | Small molecule |
| Compound Name: | HYDROCHLOROTHIAZIDE |
| Synonyms: | APO-HYDRO|APRESAZIDE|CAROZIDE|CHLOROSULTHIADIL|COPALIA-HCT|DAFIRO-HCT|DIHYDROCHLORURITE|ESIDREX|EXFORGE-HCT|Esidrix|HCTZ|HIDROTIAZIDA|HYDRO-D|HYDROCHLOROTHIAIZIDE|HYDROCHLOROTHIAZIDE|HYDROCHLOROTHIAZIDE INTENSOL|HYDROCHLOROTHIAZIDUM|HYDROSALURIC|Hydrochlorothiazide|Hydrodiuril|IDROTIAZIDE|IMPRIDA-HCT|LOTENSIN HCT|MEGADIURIL|MICROZIDE|NEWTOLIDE|NSC-53477|Oretic|PANTEMON|RASILEZ-HCT|SERVITHIAZID|SU-5879|UNIPRES|VETIDREX|Zide |
| Molecular Formula: | C7H8ClN3O4S2 |
| SMILES: | NS(=O)(=O)c1cc2c(cc1Cl)NCNS2(=O)=O |
| Molecular Species: | NEUTRAL |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name | |
|---|---|---|---|---|---|---|---|
| T15 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | HMGCR | inhibitor | Enzyme | P04035 | HMDH_HUMAN | Details |
| T10 | Caspase-1 | CASP1 | inhibitor | Enzyme | P29466 | CASP1_HUMAN | Details |
| T24 | C-C chemokine receptor type 2 | CCR2 | antagonist | GPCR | P41597 | CCR2_HUMAN | Details |
| T25 | C-C chemokine receptor type 5 | CCR5 | antagonist | GPCR | P51681 | CCR5_HUMAN | Details |
| T26 | Thyroid hormone receptor beta | THRB | agonist | Nuclear hormone receptor | P10828 | THB_HUMAN | Details |