Bioactive Compound Details
| Compound ID: | B145000 |
| Source ID: | CHEMBL64391 |
| Source Type: | Small molecule |
| Compound Name: | ITRACONAZOLE |
| Synonyms: | CANDISTAT|CANDITRAL|CLADOSAL 100|FUNGITRAXX|ITRAC|ITRACONAZOLE|ITRALEK|ITRAZOLE|ITRIZOLE|NSC-759239|ONMEL|ORUNGAL|R 51,211|R-51211|SEMPERA|SPHERAZOLE CR|SPHERAZOLE IR|SPORAMELT|SPORANOX I.V.|SPORANOX-PULSE|SPORONOX|Sporanos|Sporanox|TOLSURA|TRACONAL|TRIASPORIN |
| Molecular Formula: | C35H38Cl2N8O4 |
| SMILES: | CCC(C)n1ncn(-c2ccc(N3CCN(c4ccc(OCC5COC(Cn6cncn6)(c6ccc(Cl)cc6Cl)O5)cc4)CC3)cc2)c1=O |
| Molecular Species: | NEUTRAL |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name | |
|---|---|---|---|---|---|---|---|
| T15 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | HMGCR | inhibitor | Enzyme | P04035 | HMDH_HUMAN | Details |
| T10 | Caspase-1 | CASP1 | inhibitor | Enzyme | P29466 | CASP1_HUMAN | Details |
| T24 | C-C chemokine receptor type 2 | CCR2 | antagonist | GPCR | P41597 | CCR2_HUMAN | Details |
| T25 | C-C chemokine receptor type 5 | CCR5 | antagonist | GPCR | P51681 | CCR5_HUMAN | Details |