Bioactive Compound Details
| Compound ID: | B145497 |
| Source ID: | CHEMBL84 |
| Source Type: | Small molecule |
| Compound Name: | TOPOTECAN |
| Synonyms: | HYCAMPTAMINE|HYCAMPTIN|HYCAMTIN|Hycamtin|NOGITECAN|NSC-609699|NSC-641007|POTACTASOL|SKF-104864|TOPOTECAN|Topotecan |
| Molecular Formula: | C23H23N3O5 |
| SMILES: | CC[C@@]1(O)C(=O)OCc2c1cc1n(c2=O)Cc2cc3c(CN(C)C)c(O)ccc3nc2-1 |
| Molecular Species: | BASE |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name | |
|---|---|---|---|---|---|---|---|
| T15 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | HMGCR | inhibitor | Enzyme | P04035 | HMDH_HUMAN | Details |
| T10 | Caspase-1 | CASP1 | inhibitor | Enzyme | P29466 | CASP1_HUMAN | Details |
| T24 | C-C chemokine receptor type 2 | CCR2 | antagonist | GPCR | P41597 | CCR2_HUMAN | Details |
| T25 | C-C chemokine receptor type 5 | CCR5 | antagonist | GPCR | P51681 | CCR5_HUMAN | Details |