Bioactive Compound Details
| Compound ID: | B145822 |
| Source ID: | CHEMBL960 |
| Source Type: | Small molecule |
| Compound Name: | LEFLUNOMIDE |
| Synonyms: | Arava|HWA-486|L04AA13|LEFLUNOMIDE|LEFLUNOMIDE MEDAC|LEFLUNOMIDE RATIOPHARM|LEFLUNOMIDE TEVA|LEFLUNOMIDE WINTHROP|NSC-677411|NSC-759864|REPSO|SU-101|SU101|SULOL |
| Molecular Formula: | C12H9F3N2O2 |
| SMILES: | Cc1oncc1C(=O)Nc1ccc(C(F)(F)F)cc1 |
| Molecular Species: | NEUTRAL |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name | |
|---|---|---|---|---|---|---|---|
| T15 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | HMGCR | inhibitor | Enzyme | P04035 | HMDH_HUMAN | Details |
| T10 | Caspase-1 | CASP1 | inhibitor | Enzyme | P29466 | CASP1_HUMAN | Details |
| T24 | C-C chemokine receptor type 2 | CCR2 | antagonist | GPCR | P41597 | CCR2_HUMAN | Details |
| T25 | C-C chemokine receptor type 5 | CCR5 | antagonist | GPCR | P51681 | CCR5_HUMAN | Details |
| T06 | Glucagon-like peptide 1 receptor | GLP1R | agonist | GPCR | P43220 | GLP1R_HUMAN | Details |
| T26 | Thyroid hormone receptor beta | THRB | agonist | Nuclear hormone receptor | P10828 | THB_HUMAN | Details |