Bioactive Compound Details
| Compound ID: | B000174 |
| Source ID: | CHEMBL1064 |
| Source Type: | Small molecule |
| Compound Name: | SIMVASTATIN |
| Synonyms: | C10AA01|FLOLIPID|LACERSA|MK-0733|MK-733|NSC-758706|RANZOLONT|SIMVADOR|SIMVASTATIN|SYNVINOLIN|Simvastatin hydroxy acid|ZOCOR HEART-PRO|Zocor |
| Molecular Formula: | C25H38O5 |
| SMILES: | CCC(C)(C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21 |
| Molecular Species: | NEUTRAL |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name | |
|---|---|---|---|---|---|---|---|
| T15 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | HMGCR | inhibitor | Enzyme | P04035 | HMDH_HUMAN | Details |
| T10 | Caspase-1 | CASP1 | inhibitor | Enzyme | P29466 | CASP1_HUMAN | Details |
| T24 | C-C chemokine receptor type 2 | CCR2 | antagonist | GPCR | P41597 | CCR2_HUMAN | Details |
| T25 | C-C chemokine receptor type 5 | CCR5 | antagonist | GPCR | P51681 | CCR5_HUMAN | Details |