Bioactive Compound Details
| Compound ID: | B081919 |
| Source ID: | CHEMBL160 |
| Source Type: | Protein |
| Compound Name: | CYCLOSPORINE |
| Synonyms: | 27-400|ANTIBIOTIC S-7481F1|ATOPICA|CAPIMUNE|CAPSORIN|CEQUA|CICLOSPORIN|CICLOSPORIN A|CICLOSPORINUM|CYCLOSPORIN|CYCLOSPORIN A|CYCLOSPORINE|CYCLOSPORINE A|CYCLOSPORINE MICROEMULSION|CYCLOSPORINE, MODIFIED|DEXIMUNE|EQUORAL|Gengraf|IKERVIS|MITOGARD|NEOPLANTA|NEUROSTAT|NSC-290193|Neoral|OL-27-400|OPTIMMUNE|RAMIHYPHIN A|RESTASIS MULTIDOSE|Restasis|SANDIMMUN|SANG-35|SANGCYA|SDZ-OXL-400|Sandimmune|VANQUORAL|VERKAZIA|ZINOGRAF ME |
| Molecular Formula: | C62H111N11O12 |
| SMILES: | C/C=C/C[C@@H](C)[C@@H](O)[C@H]1C(=O)N[C@@H](CC)C(=O)N(C)CC(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@H](C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N(C)[C@@H](CC(C)C)C(=O)N(C)[C@@H](C(C)C)C(=O)N1C |
| Molecular Species: | None |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name | |
|---|---|---|---|---|---|---|---|
| T15 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | HMGCR | inhibitor | Enzyme | P04035 | HMDH_HUMAN | Details |
| T10 | Caspase-1 | CASP1 | inhibitor | Enzyme | P29466 | CASP1_HUMAN | Details |
| T24 | C-C chemokine receptor type 2 | CCR2 | antagonist | GPCR | P41597 | CCR2_HUMAN | Details |
| T25 | C-C chemokine receptor type 5 | CCR5 | antagonist | GPCR | P51681 | CCR5_HUMAN | Details |
| T06 | Glucagon-like peptide 1 receptor | GLP1R | agonist | GPCR | P43220 | GLP1R_HUMAN | Details |
| T04 | Peroxisome proliferator-activated receptor delta | PPARD | agonist | Nuclear hormone receptor | Q03181 | PPARD_HUMAN | Details |
| T05 | Peroxisome proliferator-activated receptor gamma | PPARG | agonist | Nuclear hormone receptor | P37231 | PPARG_HUMAN | Details |