Associated Disease Details
| Disease ID: | I04 |
| DO ID: | 1459 |
| Disease Name: | Hypothyroidism |
| Definition: | A thyroid gland disease which involves an underproduction of thyroid hormone. https://medlineplus.gov/hypothyroidism.html |
| Synonyms: | Congenital Hypothyroidism; Thyroid deficiency; Thyroid insufficiency |
| Class: | disease of anatomical entity/ endocrine system disease/ thyroid gland disease |
| Related Drugs: | Levothyroxine |
| Mechanism: | Thyroid hormones control lipid metabolism by exhibiting specific effects on the liver and adipose tissue in a coordinated manner. Different diseases of the thyroid gland can result in hypothyroidism. Hypothyroidism is frequently associated with dyslipidemia. Hypothyroidism-associated dyslipidemia subsequently results in intrahepatic accumulation of fat, leading to nonalcoholic fatty liver disease (NAFLD), which leads to the development of hepatic insulin resistance. |
| Reference (PMIDs): | 34884625 |
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| D203 | Levothyroxine | Chemical drug | DB00451 | THRA agonist; THRB agonist | Anti-fibrosis | Under clinical trials | Details |
| D239 | Niacin | Supplement | DB00627 | NNMT binder | Hypolipidemic drug | Under clinical trials | Details |
| D277 | Pitavastatin | Chemical drug | DB08860 | HMGCR inhibitor | Enhance lipid metabolism | Failed in clinical trials | Details |
| D312 | Rosuvastatin | Chemical drug | DB01098 | HMGCR inhibitor | Enhance lipid metabolism | Under clinical trials | Details |
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria | |
|---|---|---|---|---|---|---|
| R0088 | DB00227 | approved; investigational | small molecule | Lovastatin | Therapeutic strategy associated | Details |
| R0102 | DB00279 | approved; vet_approved | small molecule | Liothyronine | Target associated | Details |
| R0227 | DB00641 | approved | small molecule | Simvastatin | Therapeutic strategy associated | Details |
| R0317 | DB00872 | approved; investigational | small molecule | Conivaptan | Indication associated | Details |
| R0413 | DB01118 | approved; investigational | small molecule | Amiodarone | Target associated | Details |
| R0475 | DB01277 | approved; investigational | biotech | Mecasermin | Indication associated | Details |
| R0534 | DB01583 | approved | small molecule | Liotrix | Target associated | Details |
| R0535 | DB01584 | approved; withdrawn | biotech | Thyroglobulin | Indication associated | Details |
| R0749 | DB05235 | investigational | small molecule | NRP409 | Indication associated | Details |
| R1224 | DB09100 | approved | biotech | Thyroid, porcine | Target associated | Details |
| Article ID | PMID | Source | Title | |
|---|---|---|---|---|
| A00224 | 35178085 | Gastroenterol Res Pract | The Risk Factors of Nonalcoholic Fatty Liver Disease in Morbidly Obese Patients Undergoing Bariatric Surgery in Iran. | Details |
| A00512 | 35056346 | Medicina (Kaunas) | Colonic Diverticulosis and Non-Alcoholic Fatty Liver Disease: Is There a Connection? | Details |
| A01061 | 34884625 | Int J Mol Sci | Hypothyroidism-Associated Dyslipidemia: Potential Molecular Mechanisms Leading to NAFLD. | Details |
| A02508 | 34347796 | PLoS One | Perchlorate exposure does not induce obesity or non-alcoholic fatty liver disease in zebrafish. | Details |
| A02678 | 34288580 | United European Gastroenterol J | Impact of thyroid disorders on the incidence of non-alcoholic fatty liver disease in Germany. | Details |
| A02866 | 34211980 | Front Cell Dev Biol | Corrigendum: Exploring the Causality Between Hypothyroidism and Non-alcoholic Fatty Liver: A Mendelian Randomization Study. | Details |
| A03170 | 34104598 | Cureus | Unraveling the Role of Hypothyroidism in Non-alcoholic Fatty Liver Disease Pathogenesis: Correlations, Conflicts, and the Current Stand. | Details |
| A03311 | 34049413 | Exp Clin Endocrinol Diabetes | Thyroid Hormone Deficiency Modifies Hepatic Lipid Droplet Morphology and Molecular Properties in Lithogenic-Diet Supplemented Mice. | Details |
| A03350 | 34032030 | J Korean Med Sci | Severe Phenotype of Non-alcoholic Fatty Liver Disease in Pediatric Patients with Subclinical Hypothyroidism: a Retrospective Multicenter Study from Korea. | Details |
| A03509 | 33977096 | Can J Gastroenterol Hepatol | NAFLD and Infection, a Nuanced Relationship. | Details |
| A03620 | 33928009 | Clin Nephrol Case Stud | Severe type-B lactic acidosis in a patient with bilateral renal Burkitt's lymphoma. | Details |
| A03678 | 33907168 | Medicine (Baltimore) | The relationship between non-alcoholic fatty liver disease and hypothyroidism: A systematic review and meta-analysis. | Details |
| A03839 | 33852514 | Eur J Gastroenterol Hepatol | Incidences of hypothyroidism and autoimmune thyroiditis are increased in patients with nonalcoholic fatty liver disease. | Details |
| A03909 | 33822817 | PLoS One | The relationship between liver histology and thyroid function tests in patients with non-alcoholic fatty liver disease (NAFLD). | Details |
| A04007 | 33791302 | Front Cell Dev Biol | Exploring the Causality Between Hypothyroidism and Non-alcoholic Fatty Liver: A Mendelian Randomization Study. | Details |
| A04657 | 33549735 | Ann Hepatol | Hepatic steatosis and respiratory diseases: a new panorama. | Details |
| A04785 | 33505943 | Can J Gastroenterol Hepatol | Association between Nonalcoholic Fatty Liver Disease and Endocrinopathies: Clinical Implications. | Details |
| A04918 | 33449917 | Endocr Connect | Pathophysiology of NASH in endocrine diseases. | Details |
| A04985 | 33425804 | Can J Gastroenterol Hepatol | Nonalcoholic Fatty Liver Disease and Type 2 Diabetes Mellitus: A Bidirectional Relationship. | Details |
| A05274 | 33317243 | Clin Mol Hepatol | Evaluation and management of extrahepatic manifestations of nonalcoholic fatty liver disease. | Details |