Repositioning Candidate Details
| Candidate ID: | R1224 |
| Source ID: | DB09100 |
| Source Type: | approved |
| Compound Type: | biotech |
| Compound Name: | Thyroid, porcine |
| Synonyms: | Pig thyroid; Porcine thyroid; Sus scrofa thyroid; Thyroid (pork); Thyroid extract, porcine |
| Molecular Formula: | -- |
| SMILES: | -- |
| DrugBank Description: | Thyroid extract is dried and powdered thyroid glands from pigs containing tiiodothyronine (T3) and thyroxine (T4) used to supplement low or absent thyroid activity. Thyroid extract has been described in literature to treat hypothyroidism since 1891 but its use dates back as far as the 6th century. Thyroid extract is no longer considered a first line therapy as it delivers a dose that is inconsistent with the stated strength of the tablet. Currently, patients are more likely to be treated with . Thyroid extracts were never FDA approved as their use in the United States predates the FDA. |
| CAS Number: | -- |
| Molecular Weight: | |
| DrugBank Indication: | Thyroid extract is indicated for replacement therapy in decreased or absent thyroid function. |
| DrugBank Pharmacology: | Thyroid extract increases the metabolic rate of patients with hypothyroidism. The therapeutic index of thyroid extract is wide, as patients can be given varying doses. The duration of action is long as thyroid extract is generally given once daily. Patients should not use thyroid extract for weight loss. |
| DrugBank MoA: | T3 binding to the thyroid hormone receptor (TR), changes the conformation of the TR, allowing it to bind to the retinoid X receptor (RXR) and form a coactivator complex. The coactivator complex has histone acetyltransferase activity, which activates genes. In the absence of T3, TR and RXR form a corepressor complex with histone deacetylase activity, which represses genes. The macroscopic effects of thyroid hormones is an increase in the metabolic rate. T4 has similar but weaker activity to T3. |
| Targets: | Thyroid hormone receptor alpha substrate; Thyroid hormone receptor beta substrate |
| Inclusion Criteria: | Target associated |
