Investigational Drug Details
| Drug ID: | D138 |
| Drug Name: | Flaxseed |
| Synonyms: | flaxseed allergenic extract; Flaxseed extract |
| Type: | Biological drug |
| DrugBank ID: | DB10708 |
| DrugBank Description: | Flax seed allergenic extract is used in allergenic testing. |
| PubChem ID: | 164475 |
| CasNo: | 8001-26-1, 94350-04-6 |
| Repositioning for NAFLD: | Yes |
| SMILES: | O1[C@@H]([C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O)CO.OC[C@@H]([C@@H](Cc1cc(OC)c(O)cc1)CO)Cc1cc(OC)c(O)cc1 |
| Structure: |
|
| InChiKey: | MJYQFWSXKFLTAY-OVEQLNGDSA-N |
| Molecular Weight: | 542.578 |
| DrugBank Targets: | -- |
| DrugBank MoA: | -- |
| DrugBank Pharmacology: | -- |
| DrugBank Indication: | -- |
| Targets: | -- |
| Therapeutic Category: | Anti-inflammatory; Antioxidant; Antineoplastic drug |
| Clinical Trial Progress: | Clinical trial on-going (NCT03734510) |
| Latest Progress: | Under clinical trials |
| Trial ID | Source ID | Phases | Status | Study Results | Start Date | Last Update Posted | |
|---|---|---|---|---|---|---|---|
| L0633 | IRCT2013111715427N1 | Phase 2 | Not Recruiting | No Results Available | 21/01/2014 | 22 February 2018 | Details |
| L0783 | NCT03734510 | Not applicable | Not recruiting | No Results Available | 06/11/2018 | 12 December 2020 | Details |
| L0804 | NCT03377153 | Not applicable | Recruiting | No Results Available | 08/12/2017 | 8 January 2018 | Details |
| L0852 | IRCT2016011125957N1 | Not applicable | Not Recruiting | No Results Available | 07/02/2016 | 22 February 2018 | Details |
| L0880 | NCT02395900 | Phase 2/Phase 3 | Not recruiting | No Results Available | 18/03/2015 | 11 April 2016 | Details |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs | |
|---|---|---|---|---|---|
| S05 | Anti-inflammatory | inflammatory | Bile acid; TNF-a inhibitor; Dual PPAR-α and -δ agonists; Toll-Like Receptor; (TLR)-4 antagonist; Caspase inhibitor; ASK-1 inhibitor | Ursodeoxycholic Acid; Pentoxifylline; Elafibranor; JKB-121; Emricasan; Selonsertib; | Details |
| Article ID | PMID | Source | Title | |
|---|---|---|---|---|
| A01721 | 34639207 | Int J Mol Sci | Flaxseed Powder Attenuates Non-Alcoholic Steatohepatitis via Modulation of Gut Microbiota and Bile Acid Metabolism through Gut-Liver Axis. | Details |
| A03797 | 33861444 | Adv Exp Med Biol | Medicinal Plants and Phytochemicals Regulating Insulin Resistance and Glucose Homeostasis in Type 2 Diabetic Patients: A Clinical Review. | Details |
| A06566 | 32824177 | Nutrients | Effects of Dietary Phytoestrogens on Hormones throughout a Human Lifespan: A Review. | Details |
| A07040 | 32647367 | Eur J Clin Nutr | The efficacy of flaxseed and hesperidin on non-alcoholic fatty liver disease: an open-labeled randomized controlled trial. | Details |
| A08768 | 31992372 | Br J Nutr | Flaxseed oil in the context of a weight loss programme ameliorates fatty liver grade in patients with non-alcoholic fatty liver disease: a randomised double-blind controlled trial. | Details |
| A15133 | 29081885 | Oxid Med Cell Longev | Dietary Flaxseed Oil Prevents Western-Type Diet-Induced Nonalcoholic Fatty Liver Disease in Apolipoprotein-E Knockout Mice. | Details |
| A16527 | 28335388 | Nutrients | A Combination of Flaxseed Oil and Astaxanthin Improves Hepatic Lipid Accumulation and Reduces Oxidative Stress in High Fat-Diet Fed Rats. | Details |
| A18338 | 27197628 | Br J Nutr | Effect of long-term ingestion of weakly oxidised flaxseed oil on biomarkers of oxidative stress in LDL-receptor knockout mice. | Details |
| A18427 | 27143762 | Poult Sci | Therapeutic effect of flax-based diets on fatty liver in aged laying hens. | Details |
| A18723 | 26983396 | Int J Food Sci Nutr | Flaxseed supplementation in non-alcoholic fatty liver disease: a pilot randomized, open labeled, controlled study. | Details |
| A20280 | 26047766 | Clin Nutr | Omega-3 polyunsaturated fatty acids in treating non-alcoholic steatohepatitis: A randomized, double-blind, placebo-controlled trial. | Details |
| A21132 | 25524630 | J Nutr Biochem | Oral exposure to the anti-pyridoxine compound 1-amino D-proline further perturbs homocysteine metabolism through the transsulfuration pathway in moderately vitamin B₆ deficient rats. | Details |
| A23603 | 23634883 | Lipids Health Dis | Flaxseed oil and alpha-lipoic acid combination ameliorates hepatic oxidative stress and lipid accumulation in comparison to lard. | Details |
| A24189 | 23139599 | World J Gastroenterol | Omega-3 fatty acids for the treatment of non-alcoholic fatty liver disease. | Details |
| A27295 | 18710604 | Br J Nutr | Flaxseed oil prevents trans-10, cis-12-conjugated linoleic acid-induced insulin resistance in mice. | Details |
| A42387 | 34699206 | J Nat Prod | Hypocholesterolemic Efficacy of Secoisolariciresinol Diglucoside and Its Polymer in Rat. | Details |
| A46338 | 19453104 | J Agric Food Chem | Flaxseed oil attenuates nonalcoholic fatty liver of hyperlipidemic hamsters. | Details |
| A47044 | 28228158 | Lipids Health Dis | Flaxseed oil ameliorates alcoholic liver disease via anti-inflammation and modulating gut microbiota in mice. | Details |
| A47065 | 27220557 | Sci Rep | Dietary α-linolenic acid-rich flaxseed oil prevents against alcoholic hepatic steatosis via ameliorating lipid homeostasis at adipose tissue-liver axis in mice. | Details |