Investigational Drug Details
| Drug ID: | D142 |
| Drug Name: | Fructose |
| Synonyms: | -- |
| Type: | Chemical drug |
| DrugBank ID: | DB04173 |
| DrugBank Description: | -- |
| PubChem ID: | 2723872 |
| CasNo: | 30237-26-4 |
| Repositioning for NAFLD: | Yes |
| SMILES: | [C@H]([C@@H](C(=O)CO)O)([C@@H](CO)O)O |
| Structure: |
|
| InChiKey: | BJHIKXHVCXFQLS-UYFOZJQFSA-N |
| Molecular Weight: | 180.156 |
| DrugBank Targets: | Maltoporin |
| DrugBank MoA: | -- |
| DrugBank Pharmacology: | -- |
| DrugBank Indication: | -- |
| Targets: | -- |
| Therapeutic Category: | Intravenous nutrition drug |
| Clinical Trial Progress: | Clinical trial on-going (NCT03783195) |
| Latest Progress: | Under clinical trials |
| Trial ID | Source ID | Phases | Status | Study Results | Start Date | Last Update Posted | |
|---|---|---|---|---|---|---|---|
| L0474 | ACTRN12619000417189 | Phase 1 | Not Recruiting | No Results Available | 14/03/2019 | 3 March 2020 | Details |
| L0484 | NCT03783195 | Not applicable | Recruiting | No Results Available | 17/12/2018 | 12 December 2020 | Details |
| L0808 | NCT03339245 | Not applicable | Not recruiting | Has Results | 07/11/2017 | 12 April 2021 | Details |
| L0819 | NCT03184376 | Not applicable | Not recruiting | No Results Available | 08/06/2017 | 16 December 2017 | Details |
| L0905 | NCT02075164 | Not applicable | Recruiting | No Results Available | 06/02/2014 | 12 December 2020 | Details |
| L0917 | NCT01930123 | Phase 2 | Not recruiting | No Results Available | 23/08/2013 | 24 January 2022 | Details |
| L0930 | NCT01696487 | Not applicable | Not recruiting | No Results Available | 01/09/2012 | 6 October 2015 | Details |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
|---|
| Article ID | PMID | Source | Title | |
|---|---|---|---|---|
| A00006 | 35256934 | Acta Pharm Sin B | Metabolic dysregulation and emerging therapeutical targets for hepatocellular carcinoma. | Details |
| A00024 | 35251356 | EFSA J | Tolerable upper intake level for dietary sugars. | Details |
| A00051 | 35242578 | Mol Genet Metab Rep | Expression signature of the Leigh syndrome French-Canadian type. | Details |
| A00141 | 35212227 | J Agric Food Chem | Targeted Lipidomics Reveal the Effects of Different Phospholipids on the Phospholipid Profiles of Hepatic Mitochondria and Endoplasmic Reticulum in High-Fat/High-Fructose-Diet-Induced Nonalcoholic Fatty Liver Disease Mice. | Details |
| A00305 | 35143711 | Clin Transl Sci | Hepatoprotective effects of semaglutide, lanifibranor and dietary intervention in the GAN diet-induced obese and biopsy-confirmed mouse model of NASH. | Details |
| A00338 | 35129307 | Liver Int | Anti-CD47 antibody treatment attenuates liver inflammation and fibrosis in experimental non-alcoholic steatohepatitis models. | Details |
| A00344 | 35126846 | World J Hepatol | Stearoyl-CoA desaturase 1: A potential target for non-alcoholic fatty liver disease?-perspective on emerging experimental evidence. | Details |
| A00350 | 35124887 | Mol Nutr Food Res | ChREBP-driven DNL and PNPLA3 Expression Induced by Liquid Fructose are Essential in the Production of Fatty Liver and Hypertriglyceridemia in a High-Fat Diet-Fed Rat Model. | Details |
| A00429 | 35087411 | Front Pharmacol | Aurantio-Obtusin Attenuates Non-Alcoholic Fatty Liver Disease Through AMPK-Mediated Autophagy and Fatty Acid Oxidation Pathways. | Details |
| A00505 | 35058605 | Eur J Clin Nutr | Effects of a low free sugar diet on the management of nonalcoholic fatty liver disease: a randomized clinical trial. | Details |
| A00548 | 35050189 | Metabolites | The Role of Fructose as a Cardiovascular Risk Factor: An Update. | Details |
| A00562 | 35046474 | Sci Rep | Hepatic galectin-3 is associated with lipid droplet area in non-alcoholic steatohepatitis in a new swine model. | Details |
| A00592 | 35036886 | JHEP Rep | Vasoconstrictor antagonism improves functional and structural vascular alterations and liver damage in rats with early NAFLD. | Details |
| A00612 | 35029027 | J Cell Mol Med | Alterations of nitric oxide homeostasis as trigger of intestinal barrier dysfunction in non-alcoholic fatty liver disease. | Details |
| A00615 | 35028346 | Data Brief | Dataset for liver metabolomic profile of highland barley Monascus purpureus went extract-treated golden hamsters with nonalcoholic fatty liver disease. | Details |
| A00638 | 35018944 | Food Funct | Ginsenoside CK ameliorates hepatic lipid accumulation via activating the LKB1/AMPK pathway in vitro and in vivo. | Details |
| A00647 | 35015019 | Food Funct | Preventive effects of black soybean polyphenols on non-alcoholic fatty liver disease in three different mouse models. | Details |
| A00662 | 35011585 | Cells | Cynanchum atratum Alleviates Non-Alcoholic Fatty Liver by Balancing Lipogenesis and Fatty Acid Oxidation in a High-Fat, High-Fructose Diet Mice Model. | Details |
| A00663 | 35010976 | Nutrients | Metabolic-Associated Fatty Liver Disease (MAFLD), Diabetes, and Cardiovascular Disease: Associations with Fructose Metabolism and Gut Microbiota. | Details |
| A00669 | 35008925 | Int J Mol Sci | Non-Alcoholic Steatohepatitis (NASH) and Organokines: What Is Now and What Will Be in the Future. | Details |