Investigational Drug Details
| Drug ID: | D147 |
| Drug Name: | Garlic |
| Synonyms: | -- |
| Type: | Biological drug |
| DrugBank ID: | DB10532 |
| DrugBank Description: | Garlic allergenic extract is used in allergenic testing. |
| PubChem ID: | 6850761 |
| CasNo: | -- |
| Repositioning for NAFLD: | Yes |
| SMILES: | S(=O)(CC(N)C(=O)O)CC=C.S(=O)(SCC=C)CC=C |
| Structure: |
|
| InChiKey: | NEVNZJWAVFPOQZ-UHFFFAOYSA-N |
| Molecular Weight: | 339.504 |
| DrugBank Targets: | -- |
| DrugBank MoA: | -- |
| DrugBank Pharmacology: | -- |
| DrugBank Indication: | -- |
| Targets: | -- |
| Therapeutic Category: | -- |
| Clinical Trial Progress: | Clinical trial on-going (IRCT20170206032417N4) |
| Latest Progress: | Under clinical trials |
| Trial ID | Source ID | Phases | Status | Study Results | Start Date | Last Update Posted | |
|---|---|---|---|---|---|---|---|
| L0458 | IRCT20190602043787N1 | Phase 2/Phase 3 | Recruiting | No Results Available | 09/08/2019 | 7 October 2019 | Details |
| L0749 | IRCT20170206032417N4 | Not applicable | Recruiting | No Results Available | 28/04/2019 | 21 May 2019 | Details |
| L0887 | IRCT2014110819853N1 | Not applicable | Not Recruiting | No Results Available | 18/12/2014 | 22 February 2018 | Details |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
|---|
| Article ID | PMID | Source | Title | |
|---|---|---|---|---|
| A00850 | 34948230 | Int J Mol Sci | It Is High Time Physicians Thought of Natural Products for Alleviating NAFLD. Is There Sufficient Evidence to Use Them? | Details |
| A01107 | 34867384 | Front Pharmacol | Effects of Nigella sativa, Camellia sinensis, and Allium sativum as Food Additives on Metabolic Disorders, a Literature Review. | Details |
| A02744 | 34262716 | Food Sci Nutr | Effect of garlic powder supplementation on blood pressure and hs-C-reactive protein among nonalcoholic fatty liver disease patients: A randomized, double-blind, placebo-controlled trial. | Details |
| A03087 | 34136174 | Food Sci Nutr | Synergistic effects of black ginseng and aged garlic extracts for the amelioration of nonalcoholic fatty liver disease (NAFLD) in mice. | Details |
| A03515 | 33974725 | Phytother Res | Effects of garlic powder supplementation on metabolic syndrome components, insulin resistance, fatty liver index, and appetite in subjects with metabolic syndrome: A randomized clinical trial. | Details |
| A03796 | 33861449 | Adv Exp Med Biol | Beneficial Effects of Plant-Derived Natural Products on Non-alcoholic Fatty Liver Disease. | Details |
| A03797 | 33861444 | Adv Exp Med Biol | Medicinal Plants and Phytochemicals Regulating Insulin Resistance and Glucose Homeostasis in Type 2 Diabetic Patients: A Clinical Review. | Details |
| A04045 | 33777674 | Acta Pharm Sin B | S-Allylmercaptocysteine improves alcoholic liver disease partly through a direct modulation of insulin receptor signaling. | Details |
| A05686 | 33158299 | Nutrients | Investigating Whether the Mediterranean Dietary Pattern Is Integrated in Routine Dietetic Practice for Management of Chronic Conditions: A National Survey of Dietitians. | Details |
| A06770 | 32753923 | Diabetes Metab Syndr Obes | Therapeutic Effects of Garlic on Hepatic Steatosis in Nonalcoholic Fatty Liver Disease Patients: A Randomized Clinical Trial. | Details |
| A07421 | 32507439 | Complement Ther Med | Effects of garlic powder supplementation on insulin resistance, oxidative stress, and body composition in patients with non-alcoholic fatty liver disease: A randomized controlled clinical trial. | Details |
| A07916 | 32312333 | Br J Nutr | Effect of garlic powder supplementation on hepatic steatosis, liver enzymes and lipid profile in patients with non-alcoholic fatty liver disease: a double-blind randomised controlled clinical trial. | Details |
| A09891 | 31573042 | Int J Mol Med | Fatty liver and alteration of the gut microbiome induced by diallyl disulfide. | Details |
| A09927 | 31557727 | Eur J Endocrinol | Association between dietary raw garlic intake and newly diagnosed nonalcoholic fatty liver disease: a population-based study. | Details |
| A10580 | 31281460 | Exp Ther Med | Aged garlic extract ameliorates fatty liver and insulin resistance and improves the gut microbiota profile in a mouse model of insulin resistance. | Details |
| A12972 | 30201879 | Diseases | Potential Therapeutic Benefits of Herbs and Supplements in Patients with NAFLD. | Details |
| A13160 | 30109182 | Acta Pharm Sin B | Garlic-derived compound S-allylmercaptocysteine inhibits hepatocarcinogenesis through targeting LRP6/Wnt pathway. | Details |
| A16463 | 28373762 | World J Gastroenterol | Traditional Chinese herbal extracts inducing autophagy as a novel approach in therapy of nonalcoholic fatty liver disease. | Details |
| A17566 | 27743130 | Eur J Nutr | Efficacy and safety of fermented garlic extract on hepatic function in adults with elevated serum gamma-glutamyl transpeptidase levels: a double-blind, randomized, placebo-controlled trial. | Details |
| A18769 | 26955623 | Adv Biomed Res | Effect of garlic powder consumption on body composition in patients with nonalcoholic fatty liver disease: A randomized, double-blind, placebo-controlled trial. | Details |