Investigational Drug Details
| Drug ID: | D169 |
| Drug Name: | Hesperidin |
| Synonyms: | (S)-(−)-hesperidin; Cirantin; Ciratin; Hesperetin 7-O-rutinoside; Hesperidin; Hesperidoside |
| Type: | Chemical drug |
| DrugBank ID: | DB04703 |
| DrugBank Description: | Hesperidin is a flavan-on glycoside found in citrus fruits. |
| PubChem ID: | 10621 |
| CasNo: | 520-26-3 |
| Repositioning for NAFLD: | Yes |
| SMILES: | O=C1c2c(O[C@@H](C1)c1cc(O)c(cc1)OC)cc(cc2O)O[C@@H]1O[C@H](CO[C@H]2[C@H](O)[C@H](O)[C@H]([C@@H](O2)C)O)[C@H]([C@@H]([C@H]1O)O)O |
| Structure: |
|
| InChiKey: | QUQPHWDTPGMPEX-QJBIFVCTSA-N |
| Molecular Weight: | 610.565 |
| DrugBank Targets: | Aurora kinase B |
| DrugBank MoA: | -- |
| DrugBank Pharmacology: | -- |
| DrugBank Indication: | -- |
| Targets: | AURKB |
| Therapeutic Category: | Antiosteoporotic drug |
| Clinical Trial Progress: | Clinical trial on-going (NCT03377153) |
| Latest Progress: | Under clinical trials |
| Trial ID | Source ID | Phases | Status | Study Results | Start Date | Last Update Posted | |
|---|---|---|---|---|---|---|---|
| L0783 | NCT03734510 | Not applicable | Not recruiting | No Results Available | 06/11/2018 | 12 December 2020 | Details |
| L0804 | NCT03377153 | Not applicable | Recruiting | No Results Available | 08/12/2017 | 8 January 2018 | Details |
| L0805 | NCT03377140 | Not applicable | Recruiting | No Results Available | 08/12/2017 | 8 January 2018 | Details |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
|---|
| Article ID | PMID | Source | Title | |
|---|---|---|---|---|
| A00102 | 35218767 | Life Sci | Hesperidin attenuates hepatic lipid accumulation in mice fed high-fat diet and oleic acid induced HepG2 via AMPK activation. | Details |
| A00308 | 35143415 | Aging (Albany NY) | Hesperidin suppresses ERS-induced inflammation in the pathogenesis of non-alcoholic fatty liver disease. | Details |
| A02426 | 34374658 | J Physiol Pharmacol | Hesperidin, a novel candidate for the successful treatment of high fat diet plus ethanol-induced fatty liver disease in mice. | Details |
| A03507 | 33977953 | Food Funct | Hesperetin ameliorates hepatic oxidative stress and inflammation via the PI3K/AKT-Nrf2-ARE pathway in oleic acid-induced HepG2 cells and a rat model of high-fat diet-induced NAFLD. | Details |
| A04420 | 33622853 | mSystems | Impaired Intestinal Akkermansia muciniphila and Aryl Hydrocarbon Receptor Ligands Contribute to Nonalcoholic Fatty Liver Disease in Mice. | Details |
| A06483 | 32862731 | Int J Food Sci Nutr | Dietary calamondin supplementation slows the progression of non-alcoholic fatty liver disease in C57BL/6 mice fed a high-fat diet. | Details |
| A06741 | 32763355 | Toxicol Appl Pharmacol | Hesperetin protects against palmitate-induced cellular toxicity via induction of GRP78 in hepatocytes. | Details |
| A06751 | 32759940 | Nutr Diabetes | Neohesperidin enhances PGC-1α-mediated mitochondrial biogenesis and alleviates hepatic steatosis in high fat diet fed mice. | Details |
| A07040 | 32647367 | Eur J Clin Nutr | The efficacy of flaxseed and hesperidin on non-alcoholic fatty liver disease: an open-labeled randomized controlled trial. | Details |
| A09966 | 31541796 | Phytomedicine | Hepatoprotective and anti-inflammatory effects of total flavonoids of Qu Zhi Ke (peel of Citrus changshan-huyou) on non-alcoholic fatty liver disease in rats via modulation of NF-κB and MAPKs. | Details |
| A10628 | 31264313 | Phytother Res | Hesperidin improves hepatic steatosis, hepatic enzymes, and metabolic and inflammatory parameters in patients with nonalcoholic fatty liver disease: A randomized, placebo-controlled, double-blind clinical trial. | Details |
| A10982 | 31093446 | Food Sci Biotechnol | Green satsuma mandarin orange (Citrus unshiu) extract reduces adiposity and induces uncoupling protein expression in skeletal muscle of obese mice. | Details |
| A12241 | 30551370 | Biomed Pharmacother | Effect of hesperidin treatment on α-Klotho/FGF-23 pathway in rats with experimentally-induced diabetes. | Details |
| A18583 | 27046953 | Yonago Acta Med | Components of Boiogito Suppress the Progression of Hypercholesterolemia and Fatty Liver Induced by High-Cholesterol Diet in Rats. | Details |
| A18802 | 26932748 | Sci Rep | Involvement of splenic iron accumulation in the development of nonalcoholic steatohepatitis in Tsumura Suzuki Obese Diabetes mice. | Details |
| A48736 | 30305645 | Sci Rep | Hesperidin and capsaicin, but not the combination, prevent hepatic steatosis and other metabolic syndrome-related alterations in western diet-fed rats. | Details |