Investigational Drug Details
| Drug ID: | D273 |
| Drug Name: | Phosphatidylcholine |
| Synonyms: | Lecithins; Phosphatidylcholine; Phospholutein |
| Type: | Chemical drug |
| DrugBank ID: | DB15834 |
| DrugBank Description: | A complex mixture of phospholipids, glycolipids, triglycerides, phosphatidylcholines, phosphatidylethanolamines, and phosphatidylinositols. |
| PubChem ID: | 6441487 |
| CasNo: | 27098-24-4 |
| Repositioning for NAFLD: | No |
| SMILES: | P(=O)(OCC[N+](C)(C)C)(OC[C@H](OC(=O)CCCCCCC/C=C\C/C=C\CCCCC)COC(=O)CCCCCCCCCCCCCCCCC)[O-] |
| Structure: |
|
| InChiKey: | FORFDCPQKJHEBF-VPUSDGANSA-N |
| Molecular Weight: | 786.129 |
| DrugBank Targets: | -- |
| DrugBank MoA: | -- |
| DrugBank Pharmacology: | -- |
| DrugBank Indication: | -- |
| Targets: | -- |
| Therapeutic Category: | -- |
| Clinical Trial Progress: | Phase 3 completed (NCT04411862) |
| Latest Progress: | Under clinical trials |
| Trial ID | Source ID | Phases | Status | Study Results | Start Date | Last Update Posted | |
|---|---|---|---|---|---|---|---|
| L0033 | NCT04109742 | Phase 2 | Withdrawn | No Results Available | December 9, 2019 | September 27, 2021 | Details |
| L0565 | ChiCTR-IOR-16009599 | Other | Not Recruiting | No Results Available | 25/10/2016 | 18 April 2017 | Details |
| L0700 | NCT04411862 | Phase 3 | Not recruiting | No Results Available | 10/05/2020 | 12 December 2020 | Details |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
|---|
| Article ID | PMID | Source | Title | |
|---|---|---|---|---|
| A00056 | 35240344 | Cell Mol Gastroenterol Hepatol | Activation of Liver mTORC1 Protects Against NASH via Dual Regulation of VLDL-TAG Secretion and De Novo Lipogenesis. | Details |
| A00141 | 35212227 | J Agric Food Chem | Targeted Lipidomics Reveal the Effects of Different Phospholipids on the Phospholipid Profiles of Hepatic Mitochondria and Endoplasmic Reticulum in High-Fat/High-Fructose-Diet-Induced Nonalcoholic Fatty Liver Disease Mice. | Details |
| A00209 | 35185113 | J Pediatr Gastroenterol Nutr | Comparison of the Lipidomic Signature of Fatty Liver in Children and Adults: A Cross-Sectional Study. | Details |
| A00832 | 34954499 | Redox Biol | Inhibition of GCN2 alleviates hepatic steatosis and oxidative stress in obese mice: Involvement of NRF2 regulation. | Details |
| A00891 | 34939051 | J Mass Spectrom Adv Clin Lab | A pilot study optimizing metabolomic and lipidomic acquisition in serum for biomarker discovery in nonalcoholic fatty liver disease. | Details |
| A01488 | 34727379 | Biomed Chromatogr | Lipidomic-based investigation into the therapeutic effects of polyene phosphatidylcholine and Babao Dan on rats with non-alcoholic fatty liver disease. | Details |
| A01521 | 34710382 | Am J Pathol | A Novel Mouse Model of Nonalcoholic Steatohepatitis Suggests that Liver Fibrosis Initiates around Lipid-Laden Macrophages. | Details |
| A01754 | 34629052 | Lipids Health Dis | Serum lipids are associated with nonalcoholic fatty liver disease: a pilot case-control study in Mexico. | Details |
| A01803 | 34609304 | Turk J Gastroenterol | Safety and Effectiveness of Essential Phospholipids Paste in Patients with Non-alcoholic Fatty Liver Disease or Viral Hepatitis. | Details |
| A01972 | 34547171 | Liver Int | The role of hepatic lipid composition in obesity-related metabolic disease. | Details |
| A02323 | 34419589 | Biochim Biophys Acta Mol Cell Biol Lipids | Loss and gain of function of Grp75 or mitofusin 2 distinctly alter cholesterol metabolism, but all promote triglyceride accumulation in hepatocytes. | Details |
| A02365 | 34401690 | JHEP Rep | Comprehensive lipidomics reveals phenotypic differences in hepatic lipid turnover in ALD and NAFLD during alcohol intoxication. | Details |
| A02583 | 34322898 | Hepatology | Guanine Nucleotide-Binding Protein G(i) Subunit Alpha 2 Exacerbates NASH Progression by Regulating Peroxiredoxin 1-Related Inflammation and Lipophagy. | Details |
| A02760 | 34256994 | Hepatobiliary Pancreat Dis Int | LC-MS-based lipidomic analysis in distinguishing patients with nonalcoholic steatohepatitis from nonalcoholic fatty liver. | Details |
| A02799 | 34235481 | Curr Res Struct Biol | A two-stage computational approach to predict novel ligands for a chemosensory receptor. | Details |
| A02909 | 34200685 | Metabolites | Metabolomic Study of High-Fat Diet-Induced Obese (DIO) and DIO Plus CCl4-Induced NASH Mice and the Effect of Obeticholic Acid. | Details |
| A03082 | 34137937 | Metabolomics | Plasma and stool metabolomics to identify microbiota derived-biomarkers of metabolic dysfunction-associated fatty liver disease: effect of PNPLA3 genotype. | Details |
| A03338 | 34036256 | JHEP Rep | A human liver chimeric mouse model for non-alcoholic fatty liver disease. | Details |
| A03508 | 33977946 | Food Funct | DHA-enriched phosphatidylserine ameliorates non-alcoholic fatty liver disease and intestinal dysbacteriosis in mice induced by a high-fat diet. | Details |
| A03860 | 33841814 | Food Sci Nutr | Functional beverages improve insulin resistance and hepatic steatosis modulating lysophospholipids in diet-induced obese rats. | Details |