Investigational Drug Details
| Drug ID: | D295 |
| Drug Name: | Qushi Huayu Decoction |
| Synonyms: | Yin Chen, Hu Zhang, Jiang Huang, Tian Ji Huang, Zhi Zi |
| Type: | Traditional medicine |
| DrugBank ID: | -- |
| DrugBank Description: | -- |
| PubChem ID: | -- |
| CasNo: | -- |
| Repositioning for NAFLD: | No |
| SMILES: | -- |
| InChiKey: | -- |
| Molecular Weight: | -- |
| DrugBank Targets: | -- |
| DrugBank MoA: | -- |
| DrugBank Pharmacology: | -- |
| DrugBank Indication: | -- |
| Targets: | AMPK activator |
| Therapeutic Category: | Improve insulin resistance |
| Clinical Trial Progress: | Clinical trial on-going (ChiCTR-IOR-17013491) |
| Latest Progress: | Under clinical trials |
| Trial ID | Source ID | Phases | Status | Study Results | Start Date | Last Update Posted | |
|---|---|---|---|---|---|---|---|
| L0565 | ChiCTR-IOR-16009599 | Other | Not Recruiting | No Results Available | 25/10/2016 | 18 April 2017 | Details |
| L0996 | ChiCTR-IOR-17013491 | Not applicable | Recruiting | -- | 2017/11/22 | 2018/3/30 | Details |
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs | |
|---|---|---|---|---|---|
| S01 | Improve insulin resistance | insulin sensitizer; insulin resistance; glucose tolerance | Biguanide: increases 5-AMP activated protein kinase signaling; SGLT-2 inhibitor; Thiazalidinedione: selective PPAR-γ agonists; GLP-1 agonist | Metformin; Empagliflozin; Canagliflozin; Rosiglitazone; Pioglitazone; Liraglutide | Details |
| Article ID | PMID | Source | Title | |
|---|---|---|---|---|
| A05565 | 33204683 | Biomed Res Int | Research on the Mechanism of Qushi Huayu Decoction in the Intervention of Nonalcoholic Fatty Liver Disease Based on Network Pharmacology and Molecular Docking Technology. | Details |
| A09323 | 31790895 | Phytomedicine | Amelioration of non-alcoholic steatohepatitis by Qushi Huayu decoction is associated with inhibition of the intestinal mitogen-activated protein kinase pathway. | Details |
| A12063 | 30618733 | Front Pharmacol | Geniposide and Chlorogenic Acid Combination Ameliorates Non-alcoholic Steatohepatitis Involving the Protection on the Gut Barrier Function in Mouse Induced by High-Fat Diet. | Details |
| A16402 | 28416740 | Oncotarget | Multi-targeting therapeutic mechanisms of the Chinese herbal medicine QHD in the treatment of non-alcoholic fatty liver disease. | Details |
| A23676 | 23573117 | Evid Based Complement Alternat Med | Qushi Huayu Decoction Inhibits Hepatic Lipid Accumulation by Activating AMP-Activated Protein Kinase In Vivo and In Vitro. | Details |
| A24959 | 22311412 | Chin J Integr Med | Chinese herbal medicine in the treatment of nonalcoholic fatty liver disease. | Details |
| A26889 | 19583937 | Zhong Xi Yi Jie He Xue Bao | [Effects of Qushi Huayu Decoction in prevention and treatment of fatty liver in rats based on adiponectin-free fatty acid pathway]. | Details |
| A36189 | 18782536 | Zhong Xi Yi Jie He Xue Bao | [Effects of Qushi Huayu Decoction on cathepsin B and tumor necrosis factor-alpha expression in rats with non-alcoholic steatohepatitis]. | Details |