Therapeutic Target Details

Target ID: T01
Target Name: 5'-AMP-activated protein kinase subunit beta-1
Synonyms: AMPK; AMPK subunit beta-1; PRKAB1; AMP-activated protein kinase, beta-1 subunit
GENE: PRKAB1
Action: activator
Class: Kinase
UniProtKB ID:Q9Y478
Entry Name: AAKB1_HUMAN
Related Drugs: Metformin; Glucophage
Mechanism: Liver-specific AMPK activation reprograms lipid metabolism, reduces liver steatosis, decreases expression of inflammation and fibrosis genes, and leads to significant therapeutic benefits in the context of diet-induced obesity. These findings further support AMPK as a target for the prevention and treatment of NAFLD.
Reference (PMIDs): 30605676

Drug ID Drug Name Type DrugBank ID Targets Category Latest Progress
D157 Glucophage Chemical drug DB00331 -- -- Under clinical trials Details
D225 Metformin Chemical drug DB00331 PRKAB1 inducer activator; ETEDH inhibitor; GPD1 inhibitor Improve insulin resistance Under clinical trials Details

Candidate ID Source ID Source Type Compound Type Candidate Name Inclusion Criteria
R0042 DB00131 approved; investigational; nutraceutical small molecule Adenosine phosphate Target associated Details

Compound ID Source ID Source Type Compound Name Molecular Weight Molecular Formula Molecular Species
B002152 CHEMBL1234833 Small molecule -- 385.47 C20H27N5O3 NEUTRAL Details
B002440 CHEMBL1257282 Small molecule -- 382.44 C20H23FN6O NEUTRAL Details
B002596 CHEMBL1278026 Small molecule -- 412.41 C23H16N4O4 NEUTRAL Details
B096684 CHEMBL183906 Small molecule -- 273.24 C11H6F3NO2S ACID Details
B105989 CHEMBL1938953 Small molecule -- 256.7 C13H9ClN4 NEUTRAL Details
B105990 CHEMBL1938954 Small molecule -- 256.7 C13H9ClN4 NEUTRAL Details
B108388 CHEMBL2017214 Small molecule -- 422.56 C21H26N8S BASE Details
B114676 CHEMBL2205426 Small molecule -- 414.47 C23H22N6O2 NEUTRAL Details
B115596 CHEMBL2333365 Small molecule -- 455.51 C23H22FN3O4S NEUTRAL Details
B116222 CHEMBL2385579 Small molecule -- 346.39 C19H18N6O NEUTRAL Details
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Article ID PMID Source Title