Investigational Drug Details
| Drug ID: | D349 |
| Drug Name: | Statins |
| Synonyms: | -- |
| Type: | Miscellany |
| DrugBank ID: | -- |
| DrugBank Description: | -- |
| PubChem ID: | -- |
| CasNo: | -- |
| Repositioning for NAFLD: | No |
| SMILES: | -- |
| InChiKey: | -- |
| Molecular Weight: | -- |
| DrugBank Targets: | -- |
| DrugBank MoA: | -- |
| DrugBank Pharmacology: | -- |
| DrugBank Indication: | -- |
| Targets: | -- |
| Therapeutic Category: | -- |
| Clinical Trial Progress: | Phase 2 on-going (NCT04679376) |
| Latest Progress: | Under clinical trials |
| Trial ID | Source ID | Phases | Status | Study Results | Start Date | Last Update Posted | |
|---|---|---|---|---|---|---|---|
| L0169 | NCT02633956 | Phase 2 | Completed | Has Results | December 4, 2015 | June 4, 2018 | Details |
| L0403 | NCT04679376 | Phase 2 | Recruiting | No Results Available | 17/12/2020 | 27 September 2021 | Details |
| L0997 | EUCTR2005-002160-28-AT | Not applicable | Completed | No Results Available | 19/08/2005 | -- | Details |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
|---|
| Article ID | PMID | Source | Title | |
|---|---|---|---|---|
| A00346 | 35126843 | World J Hepatol | Is there a role of lipid-lowering therapies in the management of fatty liver disease? | Details |
| A00385 | 35107763 | Curr Atheroscler Rep | Childhood Hypertriglyceridemia: Is It Time for a New Approach? | Details |
| A00546 | 35051605 | J Ethnopharmacol | Xiaoyao Powder in the treatment of non-alcoholic fatty liver disease: A systematic review and meta-analysis. | Details |
| A00716 | 34992072 | BMJ Open Gastroenterol | Impact of statin treatment on non-invasive tests based predictions of fibrosis in a referral pathway for NAFLD. | Details |
| A00759 | 34977520 | JHEP Rep | Real-world management of non-alcoholic steatohepatitis differs from clinical practice guideline recommendations and across regions. | Details |
| A01020 | 34901236 | Front Cardiovasc Med | Statins in Non-alcoholic Steatohepatitis. | Details |
| A01124 | 34862975 | FASEB J | Atorvastatin protects against liver and vascular damage in a model of diet induced steatohepatitis by resetting FXR and GPBAR1 signaling. | Details |
| A01147 | 34855339 | FP Essent | Liver Disease: Nonalcoholic Fatty Liver Disease. | Details |
| A01690 | 34653272 | Aliment Pharmacol Ther | Trends in statin utilisation in US adults with non-alcoholic fatty liver disease. | Details |
| A01756 | 34628383 | Georgian Med News | THE INFLUENCE OF HYPERCHOLESTEROLEMIA AND CONCOMITANT STATIN THERAPY ON THE STATE OF PLATELET-PLASMA HEMOSTASIS IN PATIENTS WITH ESSENTIAL HYPERTENSION AND NON-ALCOHOLIC FATTY LIVER DISEASE. | Details |
| A01809 | 34607067 | Clin Res Hepatol Gastroenterol | Efficacy of statins in treatment and development of non-alcoholic fatty liver disease and steatohepatitis: A systematic review and meta-analysis. | Details |
| A01931 | 34558856 | Hepatol Commun | Role of Cholesterol-Associated Steatohepatitis in the Development of NASH. | Details |
| A02330 | 34416040 | Aliment Pharmacol Ther | Review article: non-alcoholic fatty liver disease and cardiovascular diseases: associations and treatment considerations. | Details |
| A02532 | 34339764 | J Hepatol | Prevention of NAFLD-associated HCC: Role of lifestyle and chemoprevention. | Details |
| A02922 | 34198964 | Antibiotics (Basel) | Nonalcoholic Fatty Liver Disease-A Novel Risk Factor for Recurrent Clostridioides difficile Infection. | Details |
| A03095 | 34133035 | Br J Clin Pharmacol | Statin liver safety in non-alcoholic fatty liver disease: A systematic review and metanalysis. | Details |
| A03165 | 34106587 | Medicine (Baltimore) | Xuefu Zhuyu decoction for nonalcoholic fatty liver disease: A protocol for systematic review and meta-analysis. | Details |
| A03334 | 34040322 | World J Gastroenterol | Individualized treatment options for patients with non-cirrhotic and cirrhotic liver disease. | Details |
| A03404 | 34014280 | Dis Model Mech | Synergic effect of atorvastatin and ambrisentan on sinusoidal and hemodynamic alterations in a rat model of NASH. | Details |
| A03593 | 33939118 | Drugs | Targeting AMPK by Statins: A Potential Therapeutic Approach. | Details |