Investigational Drug Details
| Drug ID: | D050 |
| Drug Name: | Branched-chain amino acids |
| Synonyms: | BCAA |
| Type: | Biological drug |
| DrugBank ID: | -- |
| DrugBank Description: | -- |
| PubChem ID: | -- |
| CasNo: | -- |
| Repositioning for NAFLD: | No |
| SMILES: | -- |
| InChiKey: | -- |
| Molecular Weight: | -- |
| DrugBank Targets: | -- |
| DrugBank MoA: | -- |
| DrugBank Pharmacology: | -- |
| DrugBank Indication: | -- |
| Targets: | -- |
| Therapeutic Category: | -- |
| Clinical Trial Progress: | Clinical trial on-going (JPRN-UMIN000012351) |
| Latest Progress: | Under clinical trials |
| Trial ID | Source ID | Phases | Status | Study Results | Start Date | Last Update Posted | |
|---|---|---|---|---|---|---|---|
| L0638 | JPRN-UMIN000012351 | Not selected | Not Recruiting | No Results Available | 25/11/2013 | 2 April 2019 | Details |
| L0670 | JPRN-UMIN000004972 | Not selected | Not Recruiting | No Results Available | 01/02/2011 | 2 April 2019 | Details |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
|---|
| Article ID | PMID | Source | Title | |
|---|---|---|---|---|
| A00291 | 35150905 | Mol Metab | ITCH E3 ubiquitin ligase downregulation compromises hepatic degradation of branched-chain amino acids. | Details |
| A01446 | 34742934 | Arch Biochem Biophys | The probiotic effects of AB23A on high-fat-diet-induced non-alcoholic fatty liver disease in mice may be associated with suppressing the serum levels of lipopolysaccharides and branched-chain amino acids. | Details |
| A02295 | 34433228 | Hepatology | Up-regulation of thioesterase superfamily member 2 in skeletal muscle promotes hepatic steatosis and insulin resistance in mice. | Details |
| A02414 | 34382495 | Ann Med | Effects of PPM1K rs1440581 and rs7678928 on serum branched-chain amino acid levels and risk of cardiovascular disease. | Details |
| A02703 | 34277974 | Endocrinol Diabetes Metab | Impact of lifestyle Intervention on branched-chain amino acid catabolism and insulin sensitivity in adolescents with obesity. | Details |
| A02960 | 34183740 | Sci Rep | Circulating branch chain amino acids and improvement in liver fat content in response to exercise interventions in NAFLD. | Details |
| A03604 | 33935282 | Int J Obes (Lond) | The effect of physical activity level and exercise training on the association between plasma branched-chain amino acids and intrahepatic lipid content in participants with obesity. | Details |
| A05068 | 33388736 | Orv Hetil | Sarcopenia - 2021: Pathophysiology, diagnosis, therapy | Details |
| A05523 | 33219609 | Liver Int | Serum aromatic and branched-chain amino acids associated with NASH demonstrate divergent associations with serum lipids. | Details |
| A05764 | 33127939 | Sci Rep | Supplementation of branched-chain amino acids decreases fat accumulation in the liver through intestinal microbiota-mediated production of acetic acid. | Details |
| A05971 | 33058486 | Pediatr Obes | A branched-chain amino acid-based metabolic score can predict liver fat in children and adolescents with severe obesity. | Details |
| A06490 | 32857176 | Eur J Nutr | Dietary intake of specific amino acids and liver status in subjects with nonalcoholic fatty liver disease: fatty liver in obesity (FLiO) study. | Details |
| A06810 | 32738185 | Mol Nutr Food Res | The Gut Microbiota and Its Metabolites, Novel Targets for Treating and Preventing Non-Alcoholic Fatty Liver Disease. | Details |
| A06812 | 32738061 | Hepatology | Prenatal Exposure to Perfluoroalkyl Substances Associated With Increased Susceptibility to Liver Injury in Children. | Details |
| A07067 | 32634278 | J Intern Med | Liver mitochondrial DNA damage and genetic variability of Cytochrome b - a key component of the respirasome - drive the severity of fatty liver disease. | Details |
| A09339 | 31785600 | Biomed Chromatogr | Simultaneous determination of thirteen substances related to NAFLD in mouse brain tissue using 3-aminobutyric acid as internal standard by HPLC-FLD. | Details |
| A09358 | 31779730 | Br J Nutr | Dietary protein insufficiency: an important consideration in fatty liver disease? | Details |
| A09432 | 31752378 | Nutrients | Role of Probiotics in Non-alcoholic Fatty Liver Disease: Does Gut Microbiota Matter? | Details |
| A11384 | 30917546 | Nutrients | Non-Alcoholic Fatty Liver Disease and Risk of Incident Type 2 Diabetes: Role of Circulating Branched-Chain Amino Acids. | Details |
| A11681 | 30791794 | Expert Rev Gastroenterol Hepatol | Sarcopenia and chronic liver diseases. | Details |