Investigational Drug Details
| Drug ID: | D522 |
| Drug Name: | Caffeic acid |
| Synonyms: | Cinnamates |
| Type: | Chemical drug |
| DrugBank ID: | -- |
| DrugBank Description: | -- |
| PubChem ID: | -- |
| CasNo: | -- |
| Repositioning for NAFLD: | No |
| SMILES: | -- |
| InChiKey: | -- |
| Molecular Weight: | -- |
| DrugBank Targets: | -- |
| DrugBank MoA: | -- |
| DrugBank Pharmacology: | -- |
| DrugBank Indication: | -- |
| Targets: | STAT3 transcription factor inhibitor |
| Therapeutic Category: | -- |
| Clinical Trial Progress: | Phase 0 on-going (ChiCTR2000035899) |
| Latest Progress: | Under clinical trials |
| Trial ID | Source ID | Phases | Status | Study Results | Start Date | Last Update Posted | |
|---|---|---|---|---|---|---|---|
| L0418 | ChiCTR2000035899 | Phase 0 | Not Recruiting | No Results Available | 19/08/2020 | 24 August 2020 | Details |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
|---|
| Article ID | PMID | Source | Title | |
|---|---|---|---|---|
| A00834 | 34954022 | Free Radic Biol Med | Mitochondriotropic antioxidant based on caffeic acid AntiOxCIN4 activates Nrf2-dependent antioxidant defenses and quality control mechanisms to antagonize oxidative stress-induced cell damage. | Details |
| A03137 | 34117215 | Cell Death Dis | Liver fat storage is controlled by HNF4α through induction of lipophagy and is reversed by a potent HNF4α agonist. | Details |
| A03463 | 33992352 | Food Res Int | Caffeic acid prevents non-alcoholic fatty liver disease induced by a high-fat diet through gut microbiota modulation in mice. | Details |
| A05568 | 33204402 | Oxid Med Cell Longev | Chicoric Acid Ameliorates Nonalcoholic Fatty Liver Disease via the AMPK/Nrf2/NFκB Signaling Pathway and Restores Gut Microbiota in High-Fat-Diet-Fed Mice. | Details |
| A05908 | 33079307 | Arch Pharm Res | Emerging roles of ferroptosis in liver pathophysiology. | Details |
| A09290 | 31804025 | Environ Toxicol | Burdock (Arctium lappa L.) root attenuates preneoplastic lesion development in a diet and thioacetamide-induced model of steatohepatitis-associated hepatocarcinogenesis. | Details |
| A10338 | 31384531 | Acta Pharm Sin B | Ablation of gut microbiota alleviates obesity-induced hepatic steatosis and glucose intolerance by modulating bile acid metabolism in hamsters. | Details |
| A12649 | 30347674 | Nutrients | Effects of Unfiltered Coffee and Bioactive Coffee Compounds on the Development of Metabolic Syndrome Components in a High-Fat-/High-Fructose-Fed Rat Model. | Details |
| A13316 | 30036051 | J Agric Food Chem | Cichoric Acid Prevents Free-Fatty-Acid-Induced Lipid Metabolism Disorders via Regulating Bmal1 in HepG2 Cells. | Details |
| A13462 | 29960159 | Nutrition | Caffeic acid ameliorates hepatic steatosis and reduces ER stress in high fat diet-induced obese mice by regulating autophagy. | Details |
| A13692 | 29803928 | Biomed Pharmacother | Protective effects of cichoric acid on H2O2-induced oxidative injury in hepatocytes and larval zebrafish models. | Details |
| A14242 | 29508519 | Mol Nutr Food Res | Caffeic Acid Phenethyl Ester Improves Metabolic Syndrome by Activating PPAR-γ and Inducing Adipose Tissue Remodeling in Diet-Induced Obese Mice. | Details |
| A14721 | 29271886 | Nutrients | A Combination of Coffee Compounds Shows Insulin-Sensitizing and Hepatoprotective Effects in a Rat Model of Diet-Induced Metabolic Syndrome. | Details |
| A16002 | 28618991 | Curr Med Chem | Effects of Polyphenolic Derivatives on Heme Oxygenase-System in Metabolic Dysfunctions. | Details |
| A16019 | 28608557 | J Food Sci | Salicornia Extract Ameliorates Salt-Induced Aggravation of Nonalcoholic Fatty Liver Disease in Obese Mice Fed a High-Fat Diet. | Details |
| A16169 | 28526925 | Eur J Nutr | Polyphenolic extract attenuates fatty acid-induced steatosis and oxidative stress in hepatic and endothelial cells. | Details |
| A16432 | 28393690 | Curr Med Chem | Hepatic AMP Kinase as a Potential Target for Treating Nonalcoholic Fatty Liver Disease: Evidence from Studies of Natural Products. | Details |
| A16560 | 28317281 | Mol Nutr Food Res | Comparison of dietary polyphenols for protection against molecular mechanisms underlying nonalcoholic fatty liver disease in a cell model of steatosis. | Details |
| A17120 | 27981809 | Mol Nutr Food Res | Chicoric acid attenuate a nonalcoholic steatohepatitis by inhibiting key regulators of lipid metabolism, fibrosis, oxidation, and inflammation in mice with methionine and choline deficiency. | Details |
| A23119 | 24027117 | J Sci Food Agric | The inhibition of oleic acid induced hepatic lipogenesis and the promotion of lipolysis by caffeic acid via up-regulation of AMP-activated kinase. | Details |