Investigational Drug Details
| Drug ID: | D538 |
| Drug Name: | Mazindol |
| Synonyms: | Sanorex |
| Type: | Chemical drug |
| DrugBank ID: | DB00579 |
| DrugBank Description: | Mazindol is a sympathomimetic used to treat obesity in combination with lifestyle modifications. |
| PubChem ID: | -- |
| CasNo: | 22232-71-9 |
| Repositioning for NAFLD: | Yes |
| SMILES: | OC1(N2CCN=C2C2=CC=CC=C12)C1=CC=C(Cl)C=C1 |
| Structure: |
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| InChiKey: | ZPXSCAKFGYXMGA-UHFFFAOYSA-N |
| Molecular Weight: | 284.74 |
| DrugBank Targets: | Sodium-dependent noradrenaline transporter inhibitor; Sodium-dependent dopamine transporter inhibitor; Sodium-dependent serotonin transporter inhibitor; Synaptic vesicular amine transporter |
| DrugBank MoA: | Unlike other sympathomimetic appetite suppressants such as phentermine, mazindol is thought to inhibit the reuptake of norepinephrine rather than to cause its release. |
| DrugBank Pharmacology: | Mazindol is a sympathomimetic amine that stimulates the central nervous system (nerves and brain), leading to increased your heart rate and blood pressure, and decreased appetite. Since the appetite-suppressing effect of the drug tends to decrease after few weeks of treatment, sympathomimetic appetite suppressants are typically used short-term weight-loss program. |
| DrugBank Indication: | Used in short-term (a few weeks) treatment of exogenous obesity in conjunction with a regimen of weight reduction based on caloric restriction, exercise, and behavior modification in patients with a body mass index of 30 kg of body weight per height in meters squared (kg/m2) or in patients with a body mass index of 27 kg/m2 in the presence of risk factors such as hypertension, diabetes, or hyperlipidemia. |
| Targets: | -- |
| Therapeutic Category: | -- |
| Clinical Trial Progress: | Clinical trial on-going (JPRN-UMIN000022879) |
| Latest Progress: | Under clinical trials |
| Trial ID | Source ID | Phases | Status | Study Results | Start Date | Last Update Posted | |
|---|---|---|---|---|---|---|---|
| L0579 | JPRN-UMIN000022879 | Not selected | Not Recruiting | No Results Available | 01/07/2016 | 2 April 2019 | Details |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
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| Article ID | PMID | Source | Title |
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