Investigational Drug Details
| Drug ID: | D596 |
| Drug Name: | Emodin |
| Synonyms: | Emodol |
| Type: | Chemical drug |
| DrugBank ID: | -- |
| DrugBank Description: | -- |
| PubChem ID: | -- |
| CasNo: | -- |
| Repositioning for NAFLD: | No |
| SMILES: | -- |
| InChiKey: | -- |
| Molecular Weight: | -- |
| DrugBank Targets: | -- |
| DrugBank MoA: | -- |
| DrugBank Pharmacology: | -- |
| DrugBank Indication: | -- |
| Targets: | DNA synthesis inhibitors; Protein synthesis inhibitors; Protein tyrosine kinase inhibitors; RNA synthesis inhibitors |
| Therapeutic Category: | Anti-fibrosis |
| Clinical Trial Progress: | -- |
| Latest Progress: | Under investigation |
| Trial ID | Source ID | Phases | Status | Study Results | Start Date | Last Update Posted |
|---|
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs | |
|---|---|---|---|---|---|
| S03 | Anti-fibrosis | fibrosis | Angiotensin Receptor Blocker (ARB); CCR2/CCR5 antagonist; Thyroid receptor β agonist; PEGylated human FGF21 analogue; Monoclonal antibody to lysyl oxidase-like 2 (LOXL2); Galectin-3 inhibitor; FGF19 variant | Losartan; Cenicriviroc; VK-2809; MGL-3196; Pegbelfermin; Simtuzumab; GR-MD-02; NGM282 | Details |
| Article ID | PMID | Source | Title | |
|---|---|---|---|---|
| A01704 | 34649337 | Biomed Pharmacother | Jiangzhi Granule attenuates non-alcoholic steatohepatitis by suppressing TNF/NFκB signaling pathway-a study based on network pharmacology. | Details |
| A02995 | 34171397 | J Ethnopharmacol | Emodin palliates high-fat diet-induced nonalcoholic fatty liver disease in mice via activating the farnesoid X receptor pathway. | Details |
| A05012 | 33410857 | Food Funct | Aloin protects mice from diet-induced non-alcoholic steatohepatitis via activation of Nrf2/HO-1 signaling. | Details |
| A06048 | 33028928 | Sci Rep | The effects of fructose and metabolic inhibition on hepatocellular carcinoma. | Details |
| A07708 | 32382557 | Biomed Res Int | A Candidate Drug for Nonalcoholic Fatty Liver Disease: A Review of Pharmacological Activities of Polygoni Multiflori Radix. | Details |
| A07818 | 32346285 | Drug Des Devel Ther | Radix Polygoni Multiflori and Its Main Component Emodin Attenuate Non-Alcoholic Fatty Liver Disease in Zebrafish by Regulation of AMPK Signaling Pathway. | Details |
| A08884 | 31953200 | J Ethnopharmacol | Study on the protection of water extracts of Polygoni Multiflori Radix and Polygoni Multiflori Radix Praeparata against NAFLD and its mechanism. | Details |
| A16027 | 28602867 | J Ethnopharmacol | Effect of Gangjihwan on hepatic steatosis and inflammation in high fat diet-fed mice. | Details |
| A17897 | 27492505 | Hepatol Res | Emodin alleviates hepatic steatosis by inhibiting sterol regulatory element binding protein 1 activity by way of the calcium/calmodulin-dependent kinase kinase-AMP-activated protein kinase-mechanistic target of rapamycin-p70 ribosomal S6 kinase signaling pathway. | Details |
| A20319 | 26031413 | Hepatol Res | Emodin ameliorates hepatic steatosis through endoplasmic reticulum-stress sterol regulatory element-binding protein 1c pathway in liquid fructose-feeding rats. | Details |
| A20472 | 25940288 | Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi | [Emodin worsens methionine-choline-deficient diet-induced non-alcoholic fatty liver disease in mice]. | Details |
| A22225 | 24740873 | Exp Biol Med (Maywood) | Emodin attenuates systemic and liver inflammation in hyperlipidemic mice administrated with lipopolysaccharides. | Details |
| A22301 | 24680992 | J Ethnopharmacol | In vitro effects of active components of Polygonum Multiflorum Radix on enzymes involved in the lipid metabolism. | Details |
| A25164 | 22120683 | J Ethnopharmacol | Lipid regulation effects of Polygoni Multiflori Radix, its processed products and its major substances on steatosis human liver cell line L02. | Details |
| A43053 | 32693115 | J Ethnopharmacol | A review of the processed Polygonum multiflorum (Thunb.) for hepatoprotection: Clinical use, pharmacology and toxicology. | Details |
| A43107 | 32553811 | Eur J Pharmacol | The effect of emodin on liver disease -- comprehensive advances in molecular mechanisms. | Details |
| A44739 | 27484243 | Food Chem Toxicol | Hepatoprotection and hepatotoxicity of Heshouwu, a Chinese medicinal herb: Context of the paradoxical effect. | Details |
| A47139 | 25228362 | Pharmacology | Emodin ameliorates ethanol-induced fatty liver injury in mice. | Details |
| A49396 | 35765026 | J Transl Med | Rhubarb free anthraquinones improved mice nonalcoholic fatty liver disease by inhibiting NLRP3 inflammasome. | Details |
| A49540 | 35721171 | Front Pharmacol | Protective Effects and Mechanisms of Yinchen Linggui Zhugan Decoction in HFD-Induced Nonalcoholic Fatty Liver Disease Rats Based on Network Pharmacology and Experimental Verification. | Details |