Investigational Drug Details
| Drug ID: | D082 |
| Drug Name: | CK-18 |
| Synonyms: | -- |
| Type: | Miscellany |
| DrugBank ID: | -- |
| DrugBank Description: | -- |
| PubChem ID: | -- |
| CasNo: | -- |
| Repositioning for NAFLD: | No |
| SMILES: | -- |
| InChiKey: | -- |
| Molecular Weight: | -- |
| DrugBank Targets: | -- |
| DrugBank MoA: | -- |
| DrugBank Pharmacology: | -- |
| DrugBank Indication: | -- |
| Targets: | -- |
| Therapeutic Category: | -- |
| Clinical Trial Progress: | Clinical trial on-going (ChiCTR1900021534) |
| Latest Progress: | Under clinical trials |
| Trial ID | Source ID | Phases | Status | Study Results | Start Date | Last Update Posted | |
|---|---|---|---|---|---|---|---|
| L0094 | NCT03166735 | Phase 2 | Completed | Has Results | June 6, 2017 | June 11, 2020 | Details |
| L0120 | NCT00994682 | Phase 4 | Completed | Has Results | December 2008 | April 5, 2017 | Details |
| L0132 | NCT02330549 | Phase 2 | Completed | Has Results | July 17, 2015 | October 11, 2019 | Details |
| L0148 | NCT03868566 | Not applicable | Unknown status | No Results Available | August 4, 2017 | February 21, 2020 | Details |
| L0173 | NCT03970031 | Phase 3 | Not yet recruiting | No Results Available | June 2022 | July 12, 2021 | Details |
| L0207 | NCT03883607 | Phase 2 | Terminated | Has Results | June 25, 2019 | October 28, 2021 | Details |
| L0210 | NCT04521114 | Phase 2 | Active, not recruiting | No Results Available | December 1, 2020 | January 14, 2022 | Details |
| L0228 | NCT02970942 | Phase 2 | Completed | Has Results | November 30, 2016 | November 16, 2021 | Details |
| L0242 | NCT03468556 | Phase 2 | Not yet recruiting | No Results Available | December 1, 2022 | March 9, 2022 | Details |
| L0271 | NCT04342793 | Phase 2 | Recruiting | No Results Available | December 4, 2019 | January 13, 2021 | Details |
| L0318 | NCT02217475 | Phase 2 | Completed | Has Results | September 18, 2014 | May 10, 2019 | Details |
| L0325 | NCT05011305 | Phase 2 | Recruiting | No Results Available | August 18, 2021 | August 19, 2021 | Details |
| L0388 | ChiCTR2100044996 | Not applicable | Recruiting | No Results Available | 03/04/2021 | 2 November 2021 | Details |
| L0468 | NCT03938246 | Phase 2 | Not recruiting | No Results Available | 24/04/2019 | 8 November 2021 | Details |
| L0553 | EUCTR2016-002965-67-NL | Phase 2 | Authorised | No Results Available | 29/03/2017 | 17 July 2017 | Details |
| L0598 | ACTRN12615001355561 | Phase 1 | Not Recruiting | No Results Available | 14/12/2015 | 13 January 2020 | Details |
| L0625 | NCT02210715 | Phase 4 | Recruiting | No Results Available | 05/08/2014 | 16 December 2017 | Details |
| L0641 | EUCTR2013-002984-24-AT | Not applicable | Not Recruiting | No Results Available | 31/07/2013 | 16 February 2015 | Details |
| L0689 | EUCTR2008-002361-31-FR | Not applicable | Authorised | No Results Available | 27/06/2008 | 28 August 2012 | Details |
| L0723 | NCT04198805 | Phase 2 | Recruiting | No Results Available | 30/10/2019 | 24 January 2022 | Details |
| L0765 | ChiCTR1900021534 | Not applicable | Recruiting | No Results Available | 26/02/2019 | 8 April 2019 | Details |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
|---|
| Article ID | PMID | Source | Title | |
|---|---|---|---|---|
| A00146 | 35208576 | Medicina (Kaunas) | The Accuracy of Serum Biomarkers in the Diagnosis of Steatosis, Fibrosis, and Inflammation in Patients with Nonalcoholic Fatty Liver Disease in Comparison to a Liver Biopsy. | Details |
| A00278 | 35154523 | Arch Med Sci | Fibroblast growth factor 21 levels and liver inflammatory biomarkers in obese subjects after weight loss. | Details |
| A00465 | 35070018 | World J Hepatol | Non-alcoholic steatohepatitis in liver transplant recipients diagnosed by serum cytokeratin 18 and transient elastography: A prospective study. | Details |
| A00777 | 34971370 | J Clin Endocrinol Metab | Obesity Modifies the Performance of Fibrosis Biomarkers in Nonalcoholic Fatty Liver Disease. | Details |
| A02742 | 34263067 | JGH Open | Noninvasive measure of treatment response in non-alcoholic steatohepatitis: Insights from EMMINENCE and meta-analysis. | Details |
| A02762 | 34254372 | Phytother Res | The effect of (Cornus mas L.) fruit extract on liver function among patients with nonalcoholic fatty liver: A double-blind randomized clinical trial. | Details |
| A03393 | 34017413 | Am J Transl Res | Correlation of CD3+/CD4+, and serum CK-18 fragment levels with glucose and lipid metabolism in elderly type 2 diabetes patients with nonalcoholic fatty liver disease. | Details |
| A03869 | 33838673 | Nutr J | Effects of supplementation with main coffee components including caffeine and/or chlorogenic acid on hepatic, metabolic, and inflammatory indices in patients with non-alcoholic fatty liver disease and type 2 diabetes: a randomized, double-blind, placebo-controlled, clinical trial. | Details |
| A04193 | 33720620 | Ter Arkh | [Hepatocellular damage and inflammation in various forms of alcoholic liver disease]. | Details |
| A06311 | 32933141 | Int J Mol Sci | Predicting Nonalcoholic Fatty Liver Disease through a Panel of Plasma Biomarkers and MicroRNAs in Female West Virginia Population. | Details |
| A06363 | 32915852 | PLoS One | Accuracy of cytokeratin 18 (M30 and M65) in detecting non-alcoholic steatohepatitis and fibrosis: A systematic review and meta-analysis. | Details |
| A06649 | 32795119 | Metab Syndr Relat Disord | Omeprazole and Spirulina Platensis Ameliorate Steatohepatitis in Experimental Nonalcoholic Fatty Liver Disease. | Details |
| A07975 | 32292439 | Pak J Med Sci | Association of liver biomarkers and cytokeratin-18 in Nonalcoholic fatty liver disease patients. | Details |
| A08362 | 32143904 | Pathol Res Pract | The significance of IL-28B and CK-18 M30 levels in the diagnosis of non-alcoholic steatohepatitis in SD rats. | Details |
| A09328 | 31789757 | J Clin Gastroenterol | The Role of Noninvasive Tests for Differentiating NASH From NAFL and Diagnosing Advanced Fibrosis Among Patients With NAFLD. | Details |
| A09680 | 31651429 | AIDS | Vitamin E is an effective treatment for nonalcoholic steatohepatitis in HIV mono-infected patients. | Details |
| A10436 | 31336557 | Diabetes Metab Syndr | Effect of diet-induced weight loss on cytokeratin-18 levels in overweight and obese patients with liver fibrosis. | Details |
| A10469 | 31324181 | Nutr J | The effect of total anthocyanin-base standardized (Cornus mas L.) fruit extract on liver function, tumor necrosis factor α, malondealdehyde, and adiponectin in patients with non-alcoholic fatty liver: a study protocol for a double-blind randomized clinical trial. | Details |
| A11744 | 30769007 | J Hepatol | The degree of hepatic steatosis associates with impaired cardiac and autonomic function. | Details |
| A11818 | 30721572 | Liver Int | Randomized trial comparing effects of weight loss by liraglutide with lifestyle modification in non-alcoholic fatty liver disease. | Details |