Investigational Drug Details
| Drug ID: | D093 |
| Drug Name: | Cynara |
| Synonyms: | Cynara scolymus L. |
| Type: | Biological extract |
| DrugBank ID: | -- |
| DrugBank Description: | -- |
| PubChem ID: | -- |
| CasNo: | 11051-97-1 |
| Repositioning for NAFLD: | No |
| SMILES: | -- |
| InChiKey: | -- |
| Molecular Weight: | -- |
| DrugBank Targets: | -- |
| DrugBank MoA: | -- |
| DrugBank Pharmacology: | -- |
| DrugBank Indication: | -- |
| Targets: | -- |
| Therapeutic Category: | -- |
| Clinical Trial Progress: | Clinical trial completed (ISRCTN33165861) |
| Latest Progress: | Under clinical trials |
| Trial ID | Source ID | Phases | Status | Study Results | Start Date | Last Update Posted | |
|---|---|---|---|---|---|---|---|
| L0459 | ISRCTN12833814 | Not applicable | Not Recruiting | No Results Available | 07/08/2019 | 14 September 2020 | Details |
| L0721 | ISRCTN33165861 | Not applicable | Recruiting | No Results Available | 04/11/2019 | 10 December 2019 | Details |
| L0792 | IRCT20170430033730N2 | Not applicable | Not Recruiting | No Results Available | 02/07/2018 | 11 September 2018 | Details |
| L0799 | IRCT20130126012278N3 | Phase 2 | Not Recruiting | No Results Available | 21/02/2018 | 26 March 2018 | Details |
| L0807 | IRCT2017042824198N2 | Phase 3 | Recruiting | No Results Available | 19/11/2017 | 22 February 2018 | Details |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
|---|
| Article ID | PMID | Source | Title | |
|---|---|---|---|---|
| A00207 | 35186807 | Can J Gastroenterol Hepatol | Therapeutic Effects of Milk Thistle (Silybum marianum L.) and Artichoke (Cynara scolymus L.) on Nonalcoholic Fatty Liver Disease in Type 2 Diabetic Rats. | Details |
| A01847 | 34591699 | J Med Food | Artichoke Extract Directly Suppresses Inflammation and Apoptosis in Hepatocytes During the Development of Non-Alcoholic Fatty Liver Disease. | Details |
| A02006 | 34533249 | Phytother Res | The effects of co-administration of artichoke leaf extract supplementation with metformin and vitamin E in patients with nonalcoholic fatty liver disease: A randomized clinical trial. | Details |
| A02408 | 34383355 | Int J Clin Pract | The effects of Cynara scolymus L. supplementation on liver enzymes: A systematic review and meta-analysis. | Details |
| A04890 | 33465383 | Complement Ther Med | Effects of artichoke on blood pressure: A systematic review and meta-analysis. | Details |
| A06508 | 32849284 | Front Endocrinol (Lausanne) | Randomized Clinical Trial: Bergamot Citrus and Wild Cardoon Reduce Liver Steatosis and Body Weight in Non-diabetic Individuals Aged Over 50 Years. | Details |
| A06990 | 32670822 | J Tradit Complement Med | The synergistic effect of Citrus bergamia and Cynara cardunculus extracts on vascular inflammation and oxidative stress in non-alcoholic fatty liver disease. | Details |
| A07601 | 32429274 | Nutrients | The Protective Effect of Cynara Cardunculus Extract in Diet-Induced NAFLD: Involvement of OCTN1 and OCTN2 Transporter Subfamily. | Details |
| A09469 | 31731527 | Nutrients | Altilix® Supplement Containing Chlorogenic Acid and Luteolin Improved Hepatic and Cardiometabolic Parameters in Subjects with Metabolic Syndrome: A 6 Month Randomized, Double-Blind, Placebo-Controlled Study. | Details |
| A13262 | 30060507 | Nutrients | Luteolin-Enriched Artichoke Leaf Extract Alleviates the Metabolic Syndrome in Mice with High-Fat Diet-Induced Obesity. | Details |
| A14217 | 29520889 | Phytother Res | Efficacy of artichoke leaf extract in non-alcoholic fatty liver disease: A pilot double-blind randomized controlled trial. | Details |
| A14319 | 29469041 | Ann Hepatol | Natural Extracts Abolished Lipid Accumulation in Cells Harbouring non-favourable PNPLA3 genotype. | Details |
| A17580 | 27735918 | Ter Arkh | [Nonalcoholic steatohepatitis and biliary sludge in people with metabolic syndrome]. | Details |
| A32845 | 27293900 | Int J Hepatol | The Effect of Artichoke Leaf Extract on Alanine Aminotransferase and Aspartate Aminotransferase in the Patients with Nonalcoholic Steatohepatitis. | Details |
| A46384 | 19145872 | Eksp Klin Gastroenterol | [Nonalcoholic fatty liver disease and metabolic syndrome: equality of pathogenetic mechanisms and therapeutic approaches]. | Details |
| A49807 | 35631240 | Nutrients | Effect of Dietary Supplementation with Eufortyn® Colesterolo Plus on Serum Lipids, Endothelial Reactivity, Indexes of Non-Alcoholic Fatty Liver Disease and Systemic Inflammation in Healthy Subjects with Polygenic Hypercholesterolemia: The ANEMONE Study. | Details |