Investigational Drugs
Investigational drugs for NAFLD are derived from global clinical trials with the latest progress, and detailed drug properties are extracted from DrugBank and PubChem. For each drug, related therapeutic strategies, targets, and clinical trials in NAFLDkb are presented with knowledge graphs.
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581 records.
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| D403 | Avandia | Chemical drug | -- | -- | -- | Under clinical trials | Details |
| D404 | Chlorella Vulgaris | Supplement | -- | -- | Prebiotics | Under clinical trials | Details |
| D405 | Evoglitin | Chemical drug | -- | DPP-4 inhibitor | -- | Under clinical trials | Details |
| D406 | Gemfibrozil | Chemical drug | DB01241 | PPARA agonist; SLCO1B1 inhibitor; SLC22A8 inhibitor; SLCO2B1 inhibitor; SLCO1B3 inhibitor | Hypolipidemic drug | Under investigation | Details |
| D407 | H.Pylori Eradication | Chemical drug | -- | -- | -- | Under clinical trials | Details |
| D408 | IMM-H014 | Miscellany | -- | Nrf2 activator; PDE4D inhibitor | -- | Under investigation | Details |
| D409 | Intraconazole | Chemical drug | -- | P450 inhibitor | Antimycotic drug | Under clinical trials | Details |
| D410 | MF4637 | Miscellany | -- | -- | -- | Under clinical trials | Details |
| D411 | Propofol tenofovir | Chemical drug | -- | -- | -- | Under clinical trials | Details |
| D412 | Saroglitazar Magnesium | Chemical drug | -- | -- | -- | Under clinical trials | Details |
| D413 | Zhenzhu Tiaozhi Capsule | Traditional medicine | -- | -- | -- | Under clinical trials | Details |
| D414 | Efruxifermin | Biological drug | -- | Fibroblast growth factor receptor agonist | anti-fibrotic, improves metabolic status | Under clinical trials | Details |
| D415 | Tropifexor plus Licogliflozin | Combinatory | -- | FXR agonist & SGLTs inhibitor | -- | Under clinical trials | Details |
| D416 | Tropifexor plus Cenicriviroc | Combinatory | -- | FXR agonist & CCR2/5 antagonist | -- | Under clinical trials | Details |
| D417 | Tropifexor plus LYS006 | Combinatory | -- | FXR agonist & leukotriene A4 hydrolase inhibitor | -- | Under clinical trials | Details |
| D418 | MET409 plus Empagliflozin | Combinatory | -- | FXR agonist & Sodium-glucose cotransporter 2 inhibitors (SGLT2i) | -- | Under clinical trials | Details |
| D443 | Pioglitazone plus Empagliflozin | Combinatory | -- | Thiazolidinediones (TZD) & SGLT2i | -- | Under clinical trials | Details |
| D444 | Obeticholic acid plus Atorvastatin | Combinatory | -- | FXR agonist & HMG CoA reductase inhibitor | -- | Under clinical trials | Details |
| D445 | PF-06865571 plus PF-05221304 | Combinatory | -- | Diacylglycerol acyltransferase 2 (DGAT2) inhibitor & acetyl CoA carboxylase (ACC) inhibitor | -- | Under clinical trials | Details |
| D446 | PF-06865571 plus PF-05221304 | Combinatory | -- | DGAT2 inhibitor & ACC inhibitor | -- | Under clinical trials | Details |
| D447 | PF-06865571 plus PF-05221304 | Combinatory | -- | DGAT2 inhibitor & ACC inhibitor | -- | Under clinical trials | Details |
| D448 | Semaglutide + Cilofexor + Firsocostat | Combinatory | -- | GLP1 receptor agonist & FXR agonist & ACC inhibitor | -- | Under clinical trials | Details |
| D449 | Semaglutide + (Cilofexor or/and Firsocostat) | Combinatory | -- | GLP1 receptor agonist & FXR agonist & ACC inhibitor | -- | Under clinical trials | Details |
| D450 | Selonsertib + Firsocostat + Cilofexor | Combinatory | -- | ASK1 inhibitor & ACC inhibitor & FXR agonist | -- | Under clinical trials | Details |
| D451 | Selonsertib + Firsocostat, Cilofexor, Fenofibrate or Vascepa | Combinatory | -- | ASK1 inhibitor & ACC inhibitor & FXR agonist & PPAR-α activator & icosapent ethyl | -- | Under clinical trials | Details |
| D452 | Elobixibat + Cholestyramine | Combinatory | -- | Ileal bile acid transporter (IBAT) inhibitor & bile acid sequestrant | -- | Under clinical trials | Details |
| D453 | Vitamin E + Omega-3 fatty acid | Combinatory | -- | -- | Antioxidant | Under clinical trials | Details |
| D454 | Vitamin E + Saraglitazar + Lifestyle Changes | Combinatory | -- | PPARα/γ agonist | Antioxidant | Under clinical trials | Details |
| D455 | NNC0194 0499 + Semaglutide + NNC0174 0833 | Combinatory | -- | GLP1 receptor agonist & islet amyloid polypeptide (IAPP) analogue | -- | Under clinical trials | Details |
| D456 | Probiotics and Glutamine, Quercetin, Vitamin E, Curcumin, Silybin, Pectin | Combinatory | -- | -- | Complex | Under clinical trials | Details |
| D458 | Breviscapine | Biological extract | -- | -- | -- | Under investigation | Details |
| D459 | ECC0509 | Chemical drug | -- | semicarbazide-sensitive amine oxidase (SSAO) inhibitor; vascular adhesion protein-1 (VAP-1) inhibitor | -- | Under clinical trials | Details |
| D460 | HU6 | Biological drug | -- | -- | Controlled Metabolic Accelerators | Under clinical trials | Details |
| D461 | ALG-055009 | Chemical drug | -- | Thyroid hormone receptor beta agonist | -- | Under clinical trials | Details |
| D462 | ALN-HSD | Biological drug | -- | -- | -- | Under clinical trials | Details |
| D463 | Alphalipoic acid | Chemical drug | DB00166 | -- | -- | Under clinical trials | Details |
| D464 | AMG 609 | Biological drug | -- | -- | -- | Under clinical trials | Details |
| D465 | Amlexanox | Chemical drug | DB01025 | -- | -- | Under clinical trials | Details |
| D466 | ASC41 | Chemical drug | -- | THR-beta agonist | -- | Under clinical trials | Details |
| D467 | ASC40 | Chemical drug | -- | Fatty Acid Synthase inhibitor | -- | Under investigation | Details |
| D468 | AZD2693 | Chemical drug | -- | -- | -- | Under clinical trials | Details |
| D469 | AZD7503 | Chemical drug | -- | -- | -- | Under clinical trials | Details |
| D470 | BAR502 | Chemical drug | -- | dual GPBAR1 and FXR agonist | -- | Under clinical trials | Details |
| D471 | BI456906 | Chemical drug | -- | GLP-1 agonist; GCG agonist | -- | Under clinical trials | Details |
| D472 | BOS-580 | Chemical drug | -- | -- | -- | Under clinical trials | Details |
| D474 | Cilostazol | Chemical drug | DB01166 | -- | -- | Under clinical trials | Details |
| D475 | DD01 | Chemical drug | -- | GLP-1R agonist; GCGR agonist | -- | Under clinical trials | Details |
| D476 | Estradiol | Chemical drug | DB00783 | -- | -- | Under clinical trials | Details |
| D477 | FM101 | Chemical drug | -- | A3 adenosine receptor modulator | -- | Under clinical trials | Details |
| D478 | GFT505 | Chemical drug | -- | -- | -- | Under clinical trials | Details |